DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DLCDDLVPEA
Uniprot ID:
C9JLJ4
Source protein:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 13
Source gene:
USP17L13
Class:
DEG_COP1_1
Location:
50:59
E3 ligase:
COP1
DEGRON score:
0.9697
ASA_SCORE:
73.23
COIL:
0.7855
CONS_SCORE:
0.4222
DSS_SCORE:
0.3621
HELIX:
0.1191
FCONS_SCORE:
1.0309
RIG_SCORE:
0.8223
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K40M
DO229084
THCA
ICGC
DLCDDLVPEA
DEG_COP1_1
0.1667
Drug responses associated with USP17L13 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLCDDLVPEA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9JLJ4
Ubiquitin carboxyl-terminal hydrolase 17-like protein 13
DEG_COP1_1
50:59
DLCDDLVPEA
COP1
0.9697
More...