DegronMD

Uniprot ID: Q6ZU35

Source protein: Capping protein-inhibiting regulator of actin dynamics

Source gene: CRACD

Class: DEG_COP1_1

Location: 794:803

E3 ligase: COP1

DEGRON score: 0.9688

ASA_SCORE: 68.22

COIL: 0.8128

CONS_SCORE: 0.6989

DSS_SCORE: 0.4027

HELIX: 0.0985

FCONS_SCORE: 1.3605

RIG_SCORE: 0.7597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P806S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DLPSFLVPSL	DEG_COP1_1	0.25
p.P804S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DLPSFLVPSL	DEG_COP1_1	0.3056
p.P801S	SIDM01609	Endometrial Carcinoma	GDSC	DLPSFLVPSL	DEG_COP1_1	0.6752
p.P807L	SIDM01617	Endometrial Carcinoma	GDSC	DLPSFLVPSL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_COP1_1	794:803	DLPSFLVPSL	COP1	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons