DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DLSMAKYSRLP
Uniprot ID:
Q8NEU8
Source protein:
DCC-interacting protein 13-beta
Source gene:
APPL2
Class:
CBL_PTK
Location:
141:151
E3 ligase:
CBL
DEGRON score:
0.9769
ASA_SCORE:
79.5455
COIL:
0.3709
CONS_SCORE:
0.7271
DSS_SCORE:
0.4595
HELIX:
0.6209
FCONS_SCORE:
1.2777
RIG_SCORE:
0.7505
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E145Q
TCGA-BT-A20J
BLCA
TCGA
DLSMAKYSRLP
CBL_PTK
0.6744
p.A136T
TCGA-CM-6171
COAD
TCGA
DLSMAKYSRLP
CBL_PTK
0.1944
p.D147A
TCGA-DR-A0ZM
CESC
TCGA
DLSMAKYSRLP
CBL_PTK
0.7793
p.M151I
DO15767
HNSC
ICGC
DLSMAKYSRLP
CBL_PTK
0.7618
p.A144E
DO228952
LICA
ICGC
DLSMAKYSRLP
CBL_PTK
0.7701
p.A144S
DO26590
LUSC
ICGC
DLSMAKYSRLP
CBL_PTK
0.7588
p.L133F
DO220875
MELA
ICGC
DLSMAKYSRLP
CBL_PTK
0.1111
p.Y138H
DO35442
PACA
ICGC
DLSMAKYSRLP
CBL_PTK
0.25
p.H132R
DO229579
PRAD
ICGC
DLSMAKYSRLP
CBL_PTK
0.0833
p.Q137H
DO42600
UCEC
ICGC
DLSMAKYSRLP
CBL_PTK
0.2222
p.F143I
SIDM01190
Bladder Carcinoma
GDSC
DLSMAKYSRLP
CBL_PTK
0.7415
p.F143I
ACH-000720
Bladder Cancer
CCLE
DLSMAKYSRLP
CBL_PTK
0.7415
p.F143I
TCCSUP
urinary_tract
COSMIC
DLSMAKYSRLP
CBL_PTK
0.7415
p.A144T
SNU-C2B
large_intestine
COSMIC
DLSMAKYSRLP
CBL_PTK
0.7139
Drug responses associated with APPL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLSMAKYSRLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEU8
DCC-interacting protein 13-beta
CBL_PTK
141:151
DLSMAKYSRLP
CBL
0.9769
More...
