DegronMD

Uniprot ID: P09874

Source protein: Poly [ADP-ribose] polymerase 1

Source gene: PARP1

Class: CBL_PTK

Location: 731:741

E3 ligase: CBL

DEGRON score: 0.9554

ASA_SCORE: 25.6182

COIL: 0.2241

CONS_SCORE: 0.6574

DSS_SCORE: 0.2182

HELIX: 0.7216

FCONS_SCORE: 1.6268

RIG_SCORE: 0.8113

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R735C	TCGA-A5-A0G2	UCEC	TCGA	DLSNRFYTLIP	CBL_PTK	0.719
p.R735C	TCGA-EE-A29E	SKCM	TCGA	DLSNRFYTLIP	CBL_PTK	0.719
p.R735C	DO222427	BTCA	ICGC	DLSNRFYTLIP	CBL_PTK	0.719
p.R735C	DO37831	SKCM	ICGC	DLSNRFYTLIP	CBL_PTK	0.719
p.R735C	DO41235	UCEC	ICGC	DLSNRFYTLIP	CBL_PTK	0.719
p.R735H	TCGA-FI-A2D5	UCEC	TCGA	DLSNRFYTLIP	CBL_PTK	0.7133
p.R735H	DO233862	GACA	ICGC	DLSNRFYTLIP	CBL_PTK	0.7133
p.R735H	DO41331	UCEC	ICGC	DLSNRFYTLIP	CBL_PTK	0.7133
p.H742N	DO229029	LICA	ICGC	DLSNRFYTLIP	CBL_PTK	0.3056
p.S725R	DO229032	LICA	ICGC	DLSNRFYTLIP	CBL_PTK	0.1667
p.P750L	DO35442	PACA	ICGC	DLSNRFYTLIP	CBL_PTK	0.0833

Drug responses associated with PARP1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Olaparib	28.9497
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Veliparib	34.5742
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Rucaparib	21.8059
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Talazoparib	15.9387
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	PARP_9495	10.6541
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	PARP_0108	0.2976
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	PARP_9482	0.5389
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Olaparib	33.499
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Olaparib	13.838
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Niraparib	4.2281
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Talazoparib	1.4429
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Olaparib	13.8814
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Veliparib	15.3598
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Rucaparib	27.6505
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Talazoparib	1.0245
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	PARP_9495	3.5931
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	PARP_0108	0.1139
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	PARP_9482	0.0405
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Olaparib	16.3944
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Olaparib	23.901
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Niraparib	9.2245
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (No)	GDSC	Talazoparib	1.572
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Olaparib	21.1217
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Veliparib	48.3284
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Rucaparib	37.6205
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Talazoparib	1.1623
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	PARP_9495	9.4335
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	PARP_0108	0.1354
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	PARP_9482	0.1094
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Olaparib	70.1044
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Olaparib	17.443
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Niraparib	16.312
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Talazoparib	0.5012
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Olaparib	139.3627
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Veliparib	153.304
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Rucaparib	128.3722
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Talazoparib	51.1424
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	PARP_9495	10.3456
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	PARP_0108	54.5668
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	PARP_9482	47.6663
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Olaparib	78.7893
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Olaparib	302.53
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Niraparib	141.68
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Talazoparib	339.57
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Olaparib	45.0438
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Veliparib	18.6869
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Rucaparib	45.0971
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Talazoparib	36.9737
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	PARP_9495	6.5918
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	PARP_0108	8.5078
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	PARP_9482	6.6211
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Olaparib	67.7565
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Olaparib	26.938
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Niraparib	68.583
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Talazoparib	51.856
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Olaparib	51.806
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Veliparib	96.1916
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Rucaparib	109.2261
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Talazoparib	2.8201
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	PARP_9495	6.8261
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	PARP_0108	1.2121
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	PARP_9482	0.7719
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Olaparib	18.7439
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Olaparib	40.03
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Niraparib	50.73
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Talazoparib	10.383
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Olaparib	8.1964
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Veliparib	31.099
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Rucaparib	12.794
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Talazoparib	3.4679
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	PARP_9495	24.3685
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	PARP_0108	0.4213
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	PARP_9482	0.1812
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Olaparib	41.1309
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Olaparib	8.3939
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Niraparib	6.5442
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Talazoparib	0.92
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Olaparib	51.806
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Veliparib	96.1916
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Rucaparib	109.2261
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Talazoparib	2.8201
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	PARP_9495	6.8261
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	PARP_0108	1.2121
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	PARP_9482	0.7719
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Olaparib	18.7439
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Olaparib	40.03
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Niraparib	50.73
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Talazoparib	10.383
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Olaparib	27.6421
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Veliparib	36.3225
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Rucaparib	39.2539
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Talazoparib	5.0437
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	PARP_9495	3.098
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	PARP_0108	0.6637
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	PARP_9482	0.5832
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Olaparib	46.1995
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Olaparib	118.27
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Niraparib	38.483
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Talazoparib	45.622
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Olaparib	84.5948
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Veliparib	73.1547
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Rucaparib	105.2562
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Talazoparib	7.1563
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	PARP_9495	3.9662
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	PARP_0108	0.5484
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	PARP_9482	0.152
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Olaparib	32.9291
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Olaparib	182.89
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Niraparib	91.197
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Talazoparib	113.44
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	Olaparib	67.1509
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	Veliparib	56.4292
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	Rucaparib	100.6875
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	Talazoparib	17.6261
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	PARP_9495	31.8819
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	PARP_0108	2.3961
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	PARP_9482	3.6494
SIDM00516	SKCM\|melanoma	p.T368M (No)	GDSC	Olaparib	104.1646
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Olaparib	144.1141
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Veliparib	119.3164
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Rucaparib	166.6094
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Talazoparib	104.3563
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	PARP_9495	8.926
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	PARP_0108	5.0618
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	PARP_9482	3.7524
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Olaparib	206.5212
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Olaparib	57.699
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Niraparib	181.63
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Olaparib	69.4471
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Veliparib	69.2845
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Rucaparib	41.005
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Talazoparib	12.7806
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	PARP_9495	4.0833
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	PARP_0108	5.4511
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	PARP_9482	4.2406
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Olaparib	72.3317
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Olaparib	164.42
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Talazoparib	130.87
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Olaparib	69.4471
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Veliparib	69.2845
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Rucaparib	41.005
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Talazoparib	12.7806
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	PARP_9495	4.0833
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	PARP_0108	5.4511
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	PARP_9482	4.2406
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Olaparib	72.3317
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Olaparib	164.42
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Talazoparib	130.87
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Olaparib	18.5867
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Veliparib	31.7423
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Rucaparib	35.6363
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Talazoparib	68.8912
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	PARP_9495	5.1378
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	PARP_0108	1.8342
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	PARP_9482	1.712
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Olaparib	57.5172
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Olaparib	127.23
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Niraparib	94.18
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Talazoparib	127.41
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Olaparib	8.6788
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Veliparib	9.893
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Rucaparib	11.1279
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Talazoparib	37.0512
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	PARP_9495	5.6984
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	PARP_0108	5.8627
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	PARP_9482	4.5774
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Olaparib	18.5833
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	Olaparib	27.8749
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	Veliparib	53.2094
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	Rucaparib	13.2125
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	Talazoparib	3.1123
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	PARP_9495	2.6107
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	PARP_0108	0.1361
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	PARP_9482	0.2891
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (No)	GDSC	Olaparib	24.282
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Olaparib	98.1894
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Veliparib	94.2574
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Rucaparib	22.4836
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Talazoparib	3.5552
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	PARP_9495	13.2069
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	PARP_0108	1.6424
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	PARP_9482	0.2739
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Olaparib	61.6087
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Olaparib	52.672
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Niraparib	74.32
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Talazoparib	8.2491
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Niraparib	298.82
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Niraparib	298.82
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Niraparib	298.82
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Olaparib	7.4285
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Veliparib	15.3437
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Rucaparib	20.0131
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	PARP_9495	9.2762
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	PARP_0108	0.1525
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	PARP_9482	0.0782
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Olaparib	32.234
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Niraparib	8.5458
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Talazoparib	35.736
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Olaparib	62.9117
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Veliparib	65.7692
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Rucaparib	69.991
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Talazoparib	23.0859
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	PARP_9495	2.9619
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	PARP_0108	2.2915
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	PARP_9482	3.2072
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Olaparib	95.5663
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Olaparib	136.22
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Niraparib	135.17
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Talazoparib	136.69
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Olaparib	90.44
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Veliparib	53.6085
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Rucaparib	13.333
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Talazoparib	61.671
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	PARP_9495	43.0997
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	PARP_0108	14.6944
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	PARP_9482	13.8673
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Olaparib	317.8826
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Olaparib	155.52
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Niraparib	41.985
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Talazoparib	132.13
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Olaparib	11.4613
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Veliparib	7.8437
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Rucaparib	7.7732
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Talazoparib	4.9053
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	PARP_9495	3.8343
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	PARP_0108	2.0604
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	PARP_9482	2.0053
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Olaparib	35.9394
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Olaparib	130.39
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Niraparib	365.31
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Talazoparib	88.499
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Olaparib	129.7192
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Veliparib	136.8174
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Rucaparib	95.4738
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Talazoparib	65.4633
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	PARP_9495	12.7941
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	PARP_0108	4.4096
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	PARP_9482	5.5348
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Olaparib	254.0929
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Olaparib	184.75
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Niraparib	48.663
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Talazoparib	19.058
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Olaparib	83.2592
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Veliparib	81.0085
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Rucaparib	61.3006
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Talazoparib	6.3291
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	PARP_9495	28.206
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	PARP_0108	37.1484
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	PARP_9482	31.4291
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Olaparib	136.3961
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Olaparib	86.73
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Niraparib	185.98
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Talazoparib	11.992
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Olaparib	36.5278
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Veliparib	93.9636
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Rucaparib	15.8752
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Talazoparib	19.0318
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	PARP_9495	29.2395
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	PARP_0108	2.1563
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	PARP_9482	2.041
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Olaparib	42.4012
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Niraparib	168.71
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Olaparib	116.1198
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Veliparib	86.8828
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Rucaparib	39.2988
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Talazoparib	0.4592
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	PARP_9495	4.4051
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	PARP_0108	0.252
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	PARP_9482	0.1025
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Olaparib	23.2666
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Olaparib	23.375
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Niraparib	28.473
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Talazoparib	0.8966
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Olaparib	47.8939
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Veliparib	47.9549
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Rucaparib	65.383
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Talazoparib	4.2808
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	PARP_9495	1.8509
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	PARP_0108	0.6792
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	PARP_9482	0.6251
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Olaparib	16.8474
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Olaparib	80.529
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Niraparib	24.426
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Talazoparib	35.805
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Olaparib	27.6421
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Veliparib	36.3225
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Rucaparib	39.2539
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Talazoparib	5.0437
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	PARP_9495	3.098
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	PARP_0108	0.6637
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	PARP_9482	0.5832
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Olaparib	46.1995
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Olaparib	118.27
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Niraparib	38.483
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Talazoparib	45.622
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Olaparib	67.5525
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Veliparib	70.5532
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Rucaparib	45.0857
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Talazoparib	14.4677
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	PARP_9495	21.3599
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	PARP_0108	4.1614
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	PARP_9482	3.2333
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Olaparib	32.4328
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Olaparib	121.5
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Niraparib	186.22
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Talazoparib	23.157
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (No)	GDSC	Niraparib	298.82
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Olaparib	26.1742
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Veliparib	35.1199
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Rucaparib	44.1009
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Talazoparib	12.5246
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	PARP_9495	5.6367
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	PARP_0108	0.6846
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	PARP_9482	0.6538
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Olaparib	40.0004
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Olaparib	23.772
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Niraparib	6.3068
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Talazoparib	1.5657
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Olaparib	149.7471
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Veliparib	151.3402
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Rucaparib	149.457
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Talazoparib	19.3772
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	PARP_9495	6.8267
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	PARP_0108	3.5898
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	PARP_9482	5.5908
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Olaparib	122.944
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Olaparib	268.93
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Niraparib	239.92
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Talazoparib	70.468
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Olaparib	149.7471
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Veliparib	151.3402
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Rucaparib	149.457
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Talazoparib	19.3772
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	PARP_9495	6.8267
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	PARP_0108	3.5898
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	PARP_9482	5.5908
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Olaparib	122.944
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Olaparib	268.93
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Niraparib	239.92
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Talazoparib	70.468
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	4.4229
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Veliparib	16.4982
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Rucaparib	2.1441
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Talazoparib	0.0368
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	PARP_9495	1.1012
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	PARP_0108	0.0297
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	PARP_9482	0.007
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	4.0485
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	3.5001
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Niraparib	94.884
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Olaparib	6.4882
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Veliparib	44.5219
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Rucaparib	9.2447
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Talazoparib	3.7021
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	PARP_9495	8.613
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	PARP_0108	0.5938
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	PARP_9482	0.7771
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Olaparib	23.2173
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Olaparib	70.474
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Niraparib	84.184
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Talazoparib	9.1241
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Olaparib	8.0181
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Veliparib	45.8528
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Rucaparib	4.1629
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Talazoparib	0.1455
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	PARP_9495	2.5711
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	PARP_0108	0.0267
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	PARP_9482	0.0123
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Olaparib	16.3352
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Olaparib	96.5067
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Veliparib	96.6953
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Rucaparib	18.2648
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Talazoparib	7.2154
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	PARP_9495	2.5473
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	PARP_0108	2.6126
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	PARP_9482	1.3137
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Olaparib	22.3609
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Olaparib	265.12
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Niraparib	327.12
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Talazoparib	44.606
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Olaparib	26.7778
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Veliparib	25.8986
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Rucaparib	35.5505
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Talazoparib	21.9763
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	PARP_9495	18.3154
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	PARP_0108	1.1372
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	PARP_9482	1.6602
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Olaparib	66.4755
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Olaparib	16.637
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Niraparib	20.122
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Talazoparib	6.4805
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	10.4611
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Veliparib	56.2188
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Rucaparib	111.6994
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Talazoparib	90.7763
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	PARP_9495	32.2639
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	PARP_0108	9.6603
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	PARP_9482	7.6581
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	65.3902
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	8.6246
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Niraparib	174.15
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Talazoparib	11.636
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Olaparib	10.4611
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Veliparib	56.2188
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Rucaparib	111.6994
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Talazoparib	90.7763
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	PARP_9495	32.2639
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	PARP_0108	9.6603
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	PARP_9482	7.6581
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Olaparib	65.3902
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Olaparib	8.6246
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Niraparib	174.15
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Talazoparib	11.636
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Olaparib	58.7209
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Veliparib	41.3761
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Rucaparib	35.9668
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Talazoparib	1.4584
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	PARP_9495	1.7049
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	PARP_0108	0.3277
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	PARP_9482	0.1251
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Olaparib	47.9735
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Olaparib	86.05
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Niraparib	26.374
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Talazoparib	4.9819
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Olaparib	5.1446
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Veliparib	30.0106
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Rucaparib	25.1956
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Talazoparib	5.9816
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	PARP_9495	6.4904
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	PARP_0108	1.0445
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	PARP_9482	0.6373
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Olaparib	23.0392
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Niraparib	140.78
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Olaparib	38.4836
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Veliparib	86.9327
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Rucaparib	69.6498
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Talazoparib	189.4873
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	PARP_9495	47.2701
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	PARP_0108	47.3718
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	PARP_9482	46.9813
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Olaparib	43.1791
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Olaparib	52.681
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Niraparib	107.1
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Talazoparib	52.448

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DLSNRFYTLIP

Degron related mutations and impact score

Drug responses associated with PARP1 mutations

All proteins holding degron of DLSNRFYTLIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09874	Poly [ADP-ribose] polymerase 1	CBL_PTK	731:741	DLSNRFYTLIP	CBL	0.9554	More...