DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DLSRGEVPEP
Uniprot ID:
Q96I82
Source protein:
Kazal-type serine protease inhibitor domain-containing protein 1
Source gene:
KAZALD1
Class:
DEG_COP1_1
Location:
115:124
E3 ligase:
COP1
DEGRON score:
0.8427
ASA_SCORE:
77
COIL:
0.8488
CONS_SCORE:
0.3765
DSS_SCORE:
0.2409
HELIX:
0.0636
FCONS_SCORE:
0.7375
RIG_SCORE:
0.7259
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S130L
TCGA-FW-A3R5
SKCM
TCGA
DLSRGEVPEP
DEG_COP1_1
0.1667
p.S130L
DO37406
SKCM
ICGC
DLSRGEVPEP
DEG_COP1_1
0.1667
p.R129H
DO227646
COCA
ICGC
DLSRGEVPEP
DEG_COP1_1
0.1944
p.G114S
SIDM00410
Other Blood Cancers
GDSC
DLSRGEVPEP
DEG_COP1_1
0.3056
p.G114S
ACH-002317
Leukemia
CCLE
DLSRGEVPEP
DEG_COP1_1
0.3056
p.G114S
YT
haematopoietic_and_lymphoid_tissue
COSMIC
DLSRGEVPEP
DEG_COP1_1
0.3056
p.P133A
SIDM00575
Glioma
GDSC
DLSRGEVPEP
DEG_COP1_1
0.0833
p.P133A
ACH-000200
Brain Cancer
CCLE
DLSRGEVPEP
DEG_COP1_1
0.0833
p.P133A
NMC-G1
central_nervous_system
COSMIC
DLSRGEVPEP
DEG_COP1_1
0.0833
Drug responses associated with KAZALD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLSRGEVPEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96I82
Kazal-type serine protease inhibitor domain-containing protein 1
DEG_COP1_1
115:124
DLSRGEVPEP
COP1
0.8427
More...