DegronMD

Uniprot ID: P27797

Source protein: Calreticulin

Source gene: CALR

Class: CBL_PTK

Location: 295:303

E3 ligase: CBL

DEGRON score: 0.9995

ASA_SCORE: 64.5333

COIL: 0.813

CONS_SCORE: 0.6626

DSS_SCORE: 0.3594

HELIX: 0.0754

FCONS_SCORE: 1.0972

RIG_SCORE: 0.7273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E298G	TCGA-AJ-A2QL	UCEC	TCGA	DNPEYSPDP	CBL_PTK	0.6087
p.E298G	DO42769	UCEC	ICGC	DNPEYSPDP	CBL_PTK	0.6087
p.S300Y	TCGA-AP-A056	UCEC	TCGA	DNPEYSPDP	CBL_PTK	0.8231
p.S300Y	DO43971	UCEC	ICGC	DNPEYSPDP	CBL_PTK	0.8231
p.V313M	TCGA-AX-A1C9	UCEC	TCGA	DNPEYSPDP	CBL_PTK	0.0556
p.V313M	DO43098	UCEC	ICGC	DNPEYSPDP	CBL_PTK	0.0556
p.D309Y	TCGA-CJ-4640	KIRC	TCGA	DNPEYSPDP	CBL_PTK	0.1667
p.D309Y	DO16202	KIRC	ICGC	DNPEYSPDP	CBL_PTK	0.1667
p.Y306C	DO234462	ESAD	ICGC	DNPEYSPDP	CBL_PTK	0.25
p.D302N	SIDM00391	Plasma Cell Myeloma	GDSC	DNPEYSPDP	CBL_PTK	0.5821
p.D302N	ACH-000363	Myeloma	CCLE	DNPEYSPDP	CBL_PTK	0.5821
p.D302N	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	DNPEYSPDP	CBL_PTK	0.5821
p.I294M	SIDM01588	Endometrial Carcinoma	GDSC	DNPEYSPDP	CBL_PTK	0.3056
p.I294M	ACH-000993	Endometrial/Uterine Cancer	CCLE	DNPEYSPDP	CBL_PTK	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27797	Calreticulin	CBL_PTK	295:303	DNPEYSPDP	CBL	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons