DegronMD

Uniprot ID: Q86YW5

Source protein: Trem-like transcript 1 protein

Source gene: TREML1

Class: CBL_PTK

Location: 241:249

E3 ligase: CBL

DEGRON score: 0.795

ASA_SCORE: 61.6

COIL: 0.6531

CONS_SCORE: 0.5772

DSS_SCORE: 0.5786

HELIX: 0.0529

FCONS_SCORE: 0.9579

RIG_SCORE: 0.6745

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G255E	TCGA-21-1079	LUSC	TCGA	DNTTYTSLP	CBL_PTK	0.1667
p.G255E	TCGA-D3-A3CB	SKCM	TCGA	DNTTYTSLP	CBL_PTK	0.1667
p.G255E	DO26846	LUSC	ICGC	DNTTYTSLP	CBL_PTK	0.1667
p.G255E	DO47386	SKCM	ICGC	DNTTYTSLP	CBL_PTK	0.1667
p.L248I	TCGA-A5-A0G2	UCEC	TCGA	DNTTYTSLP	CBL_PTK	0.6063
p.L248I	DO41235	UCEC	ICGC	DNTTYTSLP	CBL_PTK	0.6063
p.L248I	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DNTTYTSLP	CBL_PTK	0.6063
p.L248I	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DNTTYTSLP	CBL_PTK	0.6063
p.T246I	TCGA-B5-A3FC	UCEC	TCGA	DNTTYTSLP	CBL_PTK	0.7078
p.T246I	DO41871	UCEC	ICGC	DNTTYTSLP	CBL_PTK	0.7078
p.P237R	DO49537	LAML	ICGC	DNTTYTSLP	CBL_PTK	0.2222
p.P237R	DO231268	LAML	ICGC	DNTTYTSLP	CBL_PTK	0.2222
p.D241E	DO229034	LICA	ICGC	DNTTYTSLP	CBL_PTK	0.6758
p.H231P	SIDM00393	Gastric Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00254	Neuroblastoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00032	Bladder Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00793	Burkitt's Lymphoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00954	Breast Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00257	Neuroblastoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00673	Breast Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00808	Burkitt's Lymphoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00785	Acute Myeloid Leukemia	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.T246S	ACH-001628	Ovarian Cancer	CCLE	DNTTYTSLP	CBL_PTK	0.6005

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DNTTYTSLP

Degron related mutations and impact score

Drug responses associated with TREML1 mutations

All proteins holding degron of DNTTYTSLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YW5	Trem-like transcript 1 protein	CBL_PTK	241:249	DNTTYTSLP	CBL	0.795	More...