DegronMD

Uniprot ID: Q86YW5

Source protein: Trem-like transcript 1 protein

Source gene: TREML1

Class: CBL_PTK

Location: 241:249

E3 ligase: CBL

DEGRON score: 0.795

ASA_SCORE: 61.6

COIL: 0.6531

CONS_SCORE: 0.5772

DSS_SCORE: 0.5786

HELIX: 0.0529

FCONS_SCORE: 0.9579

RIG_SCORE: 0.6745

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T246I	TCGA-B5-A3FC	UCEC	TCGA	DNTTYTSLP	CBL_PTK	0.7078
p.T246I	DO41871	UCEC	ICGC	DNTTYTSLP	CBL_PTK	0.7078
p.D241E	DO229034	LICA	ICGC	DNTTYTSLP	CBL_PTK	0.6758
p.L248I	TCGA-A5-A0G2	UCEC	TCGA	DNTTYTSLP	CBL_PTK	0.6063
p.L248I	DO41235	UCEC	ICGC	DNTTYTSLP	CBL_PTK	0.6063
p.L248I	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DNTTYTSLP	CBL_PTK	0.6063
p.L248I	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DNTTYTSLP	CBL_PTK	0.6063
p.T246S	ACH-001628	Ovarian Cancer	CCLE	DNTTYTSLP	CBL_PTK	0.6005
p.P237R	DO49537	LAML	ICGC	DNTTYTSLP	CBL_PTK	0.2222
p.P237R	DO231268	LAML	ICGC	DNTTYTSLP	CBL_PTK	0.2222
p.G255E	TCGA-21-1079	LUSC	TCGA	DNTTYTSLP	CBL_PTK	0.1667
p.G255E	TCGA-D3-A3CB	SKCM	TCGA	DNTTYTSLP	CBL_PTK	0.1667
p.G255E	DO26846	LUSC	ICGC	DNTTYTSLP	CBL_PTK	0.1667
p.G255E	DO47386	SKCM	ICGC	DNTTYTSLP	CBL_PTK	0.1667
p.H231P	SIDM00393	Gastric Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00254	Neuroblastoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00032	Bladder Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00793	Burkitt's Lymphoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00954	Breast Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556
p.H231P	SIDM00257	Neuroblastoma	GDSC	DNTTYTSLP	CBL_PTK	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YW5	Trem-like transcript 1 protein	CBL_PTK	241:249	DNTTYTSLP	CBL	0.795	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons