DegronMD

Uniprot ID: Q14494

Source protein: Endoplasmic reticulum membrane sensor NFE2L1

Source gene: NFE2L1

Class: CBL_PTK

Location: 343:353

E3 ligase: CBL

DEGRON score: 0.8829

ASA_SCORE: 71.0636

COIL: 0.8643

CONS_SCORE: 0.4157

DSS_SCORE: 0.4705

HELIX: 0.0971

FCONS_SCORE: 0.9666

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S337F	DO218986	BLCA	ICGC	DPLSTNYSLAP	CBL_PTK	0.1667
p.S345F	DO5452	BRCA	ICGC	DPLSTNYSLAP	CBL_PTK	0.7982
p.S343P	DO51563	KIRP	ICGC	DPLSTNYSLAP	CBL_PTK	0.6752
p.E334G	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DPLSTNYSLAP	CBL_PTK	0.0833
p.S346N	SIDM00217	Colorectal Carcinoma	GDSC	DPLSTNYSLAP	CBL_PTK	0.5958
p.S346N	SNU-1040	large_intestine	COSMIC	DPLSTNYSLAP	CBL_PTK	0.5958
p.P345S	ACH-000905	Bladder Cancer	CCLE	DPLSTNYSLAP	CBL_PTK	0.6752
p.P345S	5637	urinary_tract	COSMIC	DPLSTNYSLAP	CBL_PTK	0.6752
p.S335N	ACH-000999	Colon/Colorectal Cancer	CCLE	DPLSTNYSLAP	CBL_PTK	0.1111
p.S335N	SNU-1040	large_intestine	COSMIC	DPLSTNYSLAP	CBL_PTK	0.1111
p.P333Q	ACH-001033	Unknown	CCLE	DPLSTNYSLAP	CBL_PTK	0.0556
p.V352M	D-245MG	central_nervous_system	COSMIC	DPLSTNYSLAP	CBL_PTK	0.7208
p.S347F	NCI-H847	lung	COSMIC	DPLSTNYSLAP	CBL_PTK	0.7982
p.G339E	NCCIT	testis	COSMIC	DPLSTNYSLAP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	CBL_PTK	343:353	DPLSTNYSLAP	CBL	0.8829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons