DegronMD

Uniprot ID: Q9HCM3

Source protein: UPF0606 protein KIAA1549

Source gene: KIAA1549

Class: DEG_COP1_1

Location: 1577:1585

E3 ligase: COP1

DEGRON score: 0.9913

ASA_SCORE: 71.5667

COIL: 0.9184

CONS_SCORE: 0.4851

DSS_SCORE: 0.4383

HELIX: 0.0474

FCONS_SCORE: 0.7989

RIG_SCORE: 0.7334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1568S	TCGA-AP-A059	UCEC	TCGA	DPTASVPSV	DEG_COP1_1	0.0833
p.A1568S	DO41361	UCEC	ICGC	DPTASVPSV	DEG_COP1_1	0.0833
p.V1585M	TCGA-AX-A2HD	UCEC	TCGA	DPTASVPSV	DEG_COP1_1	0.6097
p.V1585M	DO42608	UCEC	ICGC	DPTASVPSV	DEG_COP1_1	0.6097
p.M1570I	TCGA-AX-A2HD	UCEC	TCGA	DPTASVPSV	DEG_COP1_1	0.1389
p.M1570I	DO42608	UCEC	ICGC	DPTASVPSV	DEG_COP1_1	0.1389
p.R1594W	TCGA-F4-6856	COAD	TCGA	DPTASVPSV	DEG_COP1_1	0.0833
p.R1594W	DO9114	COAD	ICGC	DPTASVPSV	DEG_COP1_1	0.0833
p.V1582M	DO10839	ESAD	ICGC	DPTASVPSV	DEG_COP1_1	0.7208
p.V1582M	SIDM00272	Breast Carcinoma	GDSC	DPTASVPSV	DEG_COP1_1	0.7208
p.R1590S	DO49671	LIAD	ICGC	DPTASVPSV	DEG_COP1_1	0.1944
p.R1590S	DO22810	LICA	ICGC	DPTASVPSV	DEG_COP1_1	0.1944
p.R1590K	DO49671	LIAD	ICGC	DPTASVPSV	DEG_COP1_1	0.1944
p.R1590K	DO22810	LICA	ICGC	DPTASVPSV	DEG_COP1_1	0.1944
p.S1584F	DO27779	MALY	ICGC	DPTASVPSV	DEG_COP1_1	0.7982
p.S1584F	DO220877	MELA	ICGC	DPTASVPSV	DEG_COP1_1	0.7982
p.A1580T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DPTASVPSV	DEG_COP1_1	0.6028
p.A1580T	ACH-000983	Leukemia	CCLE	DPTASVPSV	DEG_COP1_1	0.6028
p.A1580T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	DPTASVPSV	DEG_COP1_1	0.6028
p.S1581G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	DPTASVPSV	DEG_COP1_1	0.5882
p.S1581G	SIDM01448	Head and Neck Carcinoma	GDSC	DPTASVPSV	DEG_COP1_1	0.5882
p.S1581G	ACH-000500	Head and Neck Cancer	CCLE	DPTASVPSV	DEG_COP1_1	0.5882
p.S1581G	ACH-002221	Lymphoma	CCLE	DPTASVPSV	DEG_COP1_1	0.5882
p.S1581G	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DPTASVPSV	DEG_COP1_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM3	UPF0606 protein KIAA1549	DEG_COP1_1	1577:1585	DPTASVPSV	COP1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons