DegronMD

Uniprot ID: P12956

Source protein: X-ray repair cross-complementing protein 6

Source gene: XRCC6

Class: DEG_APCC_DBOX_1

Location: 79:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8668

ASA_SCORE: 37.7556

COIL: 0.3554

CONS_SCORE: 0.5787

DSS_SCORE: 0.0656

HELIX: 0.0143

FCONS_SCORE: 1.2777

RIG_SCORE: 0.9117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R80Q	TCGA-A5-A2K5	UCEC	TCGA	DRDLLAVVF	DEG_APCC_DBOX_1	0.7329
p.R80Q	DO41379	UCEC	ICGC	DRDLLAVVF	DEG_APCC_DBOX_1	0.7329
p.F87L	TCGA-AP-A0LM	UCEC	TCGA	DRDLLAVVF	DEG_APCC_DBOX_1	0.587
p.F87L	DO43306	UCEC	ICGC	DRDLLAVVF	DEG_APCC_DBOX_1	0.587
p.E91K	TCGA-AX-A2HC	UCEC	TCGA	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.E91K	DO41572	UCEC	ICGC	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.E91K	SIDM00945	Colorectal Carcinoma	GDSC	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.E91K	SIDM01619	Endometrial Carcinoma	GDSC	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.E91K	ACH-000895	Colon/Colorectal Cancer	CCLE	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.E91K	ACH-000984	Endometrial/Uterine Cancer	CCLE	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.E91K	CL-34	large_intestine	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.2222
p.K94E	TCGA-EE-A2MR	SKCM	TCGA	DRDLLAVVF	DEG_APCC_DBOX_1	0.5833
p.K94E	DO37819	SKCM	ICGC	DRDLLAVVF	DEG_APCC_DBOX_1	0.5833
p.A84S	DO229019	LICA	ICGC	DRDLLAVVF	DEG_APCC_DBOX_1	0.6477
p.R80G	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRDLLAVVF	DEG_APCC_DBOX_1	0.7568
p.R80G	ACH-001638	Lymphoma	CCLE	DRDLLAVVF	DEG_APCC_DBOX_1	0.7568
p.R80G	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.7568
p.N95H	SIDM00118	Colorectal Carcinoma	GDSC	DRDLLAVVF	DEG_APCC_DBOX_1	0.1111
p.N95H	ACH-001081	Colon/Colorectal Cancer	CCLE	DRDLLAVVF	DEG_APCC_DBOX_1	0.1111
p.N95H	HCC2998	large_intestine	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.1111
p.S96L	SIDM00937	Oral Cavity Carcinoma	GDSC	DRDLLAVVF	DEG_APCC_DBOX_1	0.0833
p.S96L	ACH-000832	Head and Neck Cancer	CCLE	DRDLLAVVF	DEG_APCC_DBOX_1	0.0833
p.S96L	CAL-27	upper_aerodigestive_tract	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.0833
p.K94N	ACH-000941	Endometrial/Uterine Cancer	CCLE	DRDLLAVVF	DEG_APCC_DBOX_1	0.5833
p.G88R	H3255	lung	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.3056
p.R74Q	RL95-2	endometrium	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.3056
p.G97R	H3255	lung	COSMIC	DRDLLAVVF	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRDLLAVVF

Degron related mutations and impact score

Drug responses associated with XRCC6 mutations

All proteins holding degron of DRDLLAVVF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12956	X-ray repair cross-complementing protein 6	DEG_APCC_DBOX_1	79:87	DRDLLAVVF	APC,CDC20,FZR1	0.8668	More...