DegronMD

Uniprot ID: Q3SY00

Source protein: Testis-specific protein 10-interacting protein

Source gene: TSGA10IP

Class: DEG_SCF_SKP2-CKS1_1

Location: 507:514

E3 ligase: SKP2,CSK1

DEGRON score: 0.6437

ASA_SCORE: 110.5375

COIL: 0.8915

CONS_SCORE: 0.7116

DSS_SCORE: 0.7211

HELIX: 0.0719

FCONS_SCORE: 0.9117

RIG_SCORE: 0.5858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G510D	SIDM00680	Colorectal Carcinoma	GDSC	DREGTPRK	DEG_SCF_SKP2-CKS1_1	0.6087
p.G510D	LS-180	large_intestine	COSMIC	DREGTPRK	DEG_SCF_SKP2-CKS1_1	0.6087
p.G504E	SIDM01397	Melanoma	GDSC	DREGTPRK	DEG_SCF_SKP2-CKS1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3SY00	Testis-specific protein 10-interacting protein	DEG_SCF_SKP2-CKS1_1	507:514	DREGTPRK	SKP2,CSK1	0.6437	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons