DegronMD

Uniprot ID: Q14241

Source protein: Elongin-A

Source gene: ELOA

Class: DEG_APCC_DBOX_1

Location: 407:415

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9006

ASA_SCORE: 91.3778

COIL: 0.8498

CONS_SCORE: 0.3843

DSS_SCORE: 0.5568

HELIX: 0.13

FCONS_SCORE: 0.9509

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E399Q	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	DRKSLGSLP	DEG_APCC_DBOX_1	0.1111
p.E399Q	NCI-H322M	lung	COSMIC	DRKSLGSLP	DEG_APCC_DBOX_1	0.1111
p.E425V	SIDM01135	Pancreatic Carcinoma	GDSC	DRKSLGSLP	DEG_APCC_DBOX_1	0.0556
p.E425V	PANC-10-05	pancreas	COSMIC	DRKSLGSLP	DEG_APCC_DBOX_1	0.0556
p.R417W	IGROV-1	ovary	COSMIC	DRKSLGSLP	DEG_APCC_DBOX_1	0.2778
p.R417Q	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DRKSLGSLP	DEG_APCC_DBOX_1	0.2778
p.E399V	PANC-10-05	pancreas	COSMIC	DRKSLGSLP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14241	Elongin-A	DEG_APCC_DBOX_1	407:415	DRKSLGSLP	APC,CDC20,FZR1	0.9006	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons