DegronMD

Uniprot ID: P05129

Source protein: Protein kinase C gamma type

Source gene: PRKCG

Class: DEG_APCC_DBOX_1

Location: 658:666

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8667

ASA_SCORE: 78.6778

COIL: 0.5167

CONS_SCORE: 0.3848

DSS_SCORE: 0.3428

HELIX: 0.4604

FCONS_SCORE: 0.7229

RIG_SCORE: 0.844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A650V	TCGA-AZ-5407	COAD	TCGA	DRLVLASID	DEG_APCC_DBOX_1	0.1111
p.A650V	TCGA-DF-A2KU	UCEC	TCGA	DRLVLASID	DEG_APCC_DBOX_1	0.1111
p.A650V	DO8432	COAD	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.1111
p.A650V	DO223286	UCEC	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.1111
p.R659L	TCGA-EE-A3AE	SKCM	TCGA	DRLVLASID	DEG_APCC_DBOX_1	0.8428
p.R659L	DO37802	SKCM	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.8428
p.D666N	TCGA-VS-A9UI	CESC	TCGA	DRLVLASID	DEG_APCC_DBOX_1	0.5821
p.D666N	DO219734	CESC	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.5821
p.R659C	DO233154	GACA	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.8301
p.F670L	DO233280	GACA	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.2222
p.R649W	DO231900	LINC	ICGC	DRLVLASID	DEG_APCC_DBOX_1	0.0833
p.R659H	SIDM00491	Thyroid Gland Carcinoma	GDSC	DRLVLASID	DEG_APCC_DBOX_1	0.8244
p.R659H	ACH-001443	Thyroid Cancer	CCLE	DRLVLASID	DEG_APCC_DBOX_1	0.8244
p.R659H	ASH-3	thyroid	COSMIC	DRLVLASID	DEG_APCC_DBOX_1	0.8244
p.A651V	ACH-001862	Bile Duct Cancer	CCLE	DRLVLASID	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05129	Protein kinase C gamma type	DEG_APCC_DBOX_1	658:666	DRLVLASID	APC,CDC20,FZR1	0.8667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons