DegronMD

Uniprot ID: Q8IZ07

Source protein: Ankyrin repeat domain-containing protein 13A

Source gene: ANKRD13A

Class: DEG_APCC_DBOX_1

Location: 296:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9741

ASA_SCORE: 70.2889

COIL: 0.5779

CONS_SCORE: 0.4413

DSS_SCORE: 0.4757

HELIX: 0.3748

FCONS_SCORE: 1.409

RIG_SCORE: 0.7416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D296Y	TCGA-DD-AACF	LIHC	TCGA	DRNPLESLL	DEG_APCC_DBOX_1	0.6214
p.D296Y	DO52201	LIHC	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.6214
p.R292I	TCGA-DU-6392	LGG	TCGA	DRNPLESLL	DEG_APCC_DBOX_1	0.2222
p.R292I	DO22237	LGG	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.2222
p.E288K	TCGA-FW-A3R5	SKCM	TCGA	DRNPLESLL	DEG_APCC_DBOX_1	0.1111
p.E288K	DO37406	SKCM	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.1111
p.R292K	DO48217	ESCA	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.2222
p.E308Q	DO233673	GACA	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.2222
p.V307L	DO228941	LICA	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.25
p.V307L	DO229029	LICA	ICGC	DRNPLESLL	DEG_APCC_DBOX_1	0.25
p.E289K	SIDM01617	Endometrial Carcinoma	GDSC	DRNPLESLL	DEG_APCC_DBOX_1	0.1389
p.E289K	ACH-000994	Endometrial/Uterine Cancer	CCLE	DRNPLESLL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZ07	Ankyrin repeat domain-containing protein 13A	DEG_APCC_DBOX_1	296:304	DRNPLESLL	APC,CDC20,FZR1	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons