DegronMD

Uniprot ID: Q6NUI6

Source protein: Chondroadherin-like protein

Source gene: CHADL

Class: DEG_APCC_DBOX_1

Location: 577:585

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6964

ASA_SCORE: 69.2889

COIL: 0.8676

CONS_SCORE: 0.58

DSS_SCORE: 0.34

HELIX: 0.0158

FCONS_SCORE: 1.1934

RIG_SCORE: 0.765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A588T	TCGA-EO-A22X	UCEC	TCGA	DRNQLREVP	DEG_APCC_DBOX_1	0.25
p.A588T	DO43907	UCEC	ICGC	DRNQLREVP	DEG_APCC_DBOX_1	0.25
p.E590D	ACH-000974	Endometrial/Uterine Cancer	CCLE	DRNQLREVP	DEG_APCC_DBOX_1	0.1944
p.A568T	ACH-000980	Lung Cancer	CCLE	DRNQLREVP	DEG_APCC_DBOX_1	0.0833
p.T586I	ACH-001333	Cervical Cancer	CCLE	DRNQLREVP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUI6	Chondroadherin-like protein	DEG_APCC_DBOX_1	577:585	DRNQLREVP	APC,CDC20,FZR1	0.6964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons