DegronMD

Uniprot ID: P07093

Source protein: Glia-derived nexin

Source gene: SERPINE2

Class: DEG_APCC_DBOX_1

Location: 374:382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 22.3222

COIL: 0.2938

CONS_SCORE: 0.6389

DSS_SCORE: 0.0545

HELIX: 0.003

FCONS_SCORE: 1.3466

RIG_SCORE: 0.9287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R386G	TCGA-CG-4442	STAD	TCGA	DRPFLFFIR	DEG_APCC_DBOX_1	0.2222
p.P387L	TCGA-EB-A5UL	SKCM	TCGA	DRPFLFFIR	DEG_APCC_DBOX_1	0.1944
p.S377A	TCGA-EO-A22U	UCEC	TCGA	DRPFLFFIR	DEG_APCC_DBOX_1	0.7588
p.R382Q	DO9138	COAD	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.6218
p.R382Q	DO36556	READ	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.6218
p.L378M	DO222762	COCA	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.711
p.P376L	DO47601	SKCM	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.6471
p.R375G	DO38380	STAD	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.7568
p.P385H	DO219773	UCEC	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.25
p.V389A	DO42608	UCEC	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.1389
p.S366A	DO43755	UCEC	ICGC	DRPFLFFIR	DEG_APCC_DBOX_1	0.1111
p.V384I	SIDM00282	Colorectal Carcinoma	GDSC	DRPFLFFIR	DEG_APCC_DBOX_1	0.2778
p.V384I	CW-2	large_intestine	COSMIC	DRPFLFFIR	DEG_APCC_DBOX_1	0.2778
p.A365D	SIDM01619	Endometrial Carcinoma	GDSC	DRPFLFFIR	DEG_APCC_DBOX_1	0.0833
p.V372I	ACH-000998	Colon/Colorectal Cancer	CCLE	DRPFLFFIR	DEG_APCC_DBOX_1	0.2778
p.V372I	CW-2	large_intestine	COSMIC	DRPFLFFIR	DEG_APCC_DBOX_1	0.2778
p.V373I	CW-2	large_intestine	COSMIC	DRPFLFFIR	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07093	Glia-derived nexin	DEG_APCC_DBOX_1	374:382	DRPFLFFIR	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons