DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: DEG_APCC_DBOX_1

Location: 22:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6838

ASA_SCORE: 77.4667

COIL: 0.1424

CONS_SCORE: 0.5622

DSS_SCORE: 0.3363

HELIX: 0.8509

FCONS_SCORE: 1.2093

RIG_SCORE: 0.8211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D22V	TCGA-63-A5MM	LUSC	TCGA	DRQQLEAVY	DEG_APCC_DBOX_1	0.6674
p.D22V	DO219153	LUSC	ICGC	DRQQLEAVY	DEG_APCC_DBOX_1	0.6674
p.R23H	TCGA-AA-A01R	COAD	TCGA	DRQQLEAVY	DEG_APCC_DBOX_1	0.8244
p.R23H	DO7934	COAD	ICGC	DRQQLEAVY	DEG_APCC_DBOX_1	0.8244
p.V20M	TCGA-HT-7860	LGG	TCGA	DRQQLEAVY	DEG_APCC_DBOX_1	0.2778
p.V20M	DO22614	LGG	ICGC	DRQQLEAVY	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_APCC_DBOX_1	22:30	DRQQLEAVY	APC,CDC20,FZR1	0.6838	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons