DegronMD

Uniprot ID: Q6P2I7

Source protein: Endogenous Bornavirus-like nucleoprotein 2

Source gene: EBLN2

Class: DEG_APCC_DBOX_1

Location: 66:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.858

ASA_SCORE: 72.4444

COIL: 0.8031

CONS_SCORE: 0

DSS_SCORE: 0.687

HELIX: 0.1121

FCONS_SCORE: 0

RIG_SCORE: 0.6498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A64T	TCGA-AG-A02N	READ	TCGA	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2778
p.A64T	DO37146	READ	ICGC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2778
p.A64T	SIDM00850	Gastric Carcinoma	GDSC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2778
p.A64T	ACH-000880	Gastric Cancer	CCLE	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2778
p.A64T	AGS	stomach	COSMIC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2778
p.R84I	TCGA-AN-A046	BRCA	TCGA	DRSGLPDLQ	DEG_APCC_DBOX_1	0.0556
p.R84I	DO1285	BRCA	ICGC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.0556
p.K82T	TCGA-BS-A0UV	UCEC	TCGA	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2222
p.K82T	DO42793	UCEC	ICGC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2222
p.D72G	SIDM00633	Breast Carcinoma	GDSC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.6087
p.N83K	SIDM00741	Small Cell Lung Carcinoma	GDSC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.0833
p.P57A	SIDM00761	Small Cell Lung Carcinoma	GDSC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.0833
p.P71L	SIDM00150	Colorectal Carcinoma	GDSC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.6471
p.P71L	ACH-000969	Colon/Colorectal Cancer	CCLE	DRSGLPDLQ	DEG_APCC_DBOX_1	0.6471
p.P71L	KM12	large_intestine	COSMIC	DRSGLPDLQ	DEG_APCC_DBOX_1	0.6471
p.R67K	ACH-000879	Endometrial/Uterine Cancer	CCLE	DRSGLPDLQ	DEG_APCC_DBOX_1	0.7237
p.E78K	ACH-000999	Colon/Colorectal Cancer	CCLE	DRSGLPDLQ	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2I7	Endogenous Bornavirus-like nucleoprotein 2	DEG_APCC_DBOX_1	66:74	DRSGLPDLQ	APC,CDC20,FZR1	0.858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons