DegronMD

Uniprot ID: Q9Y5H3

Source protein: Protocadherin gamma-A10

Source gene: PCDHGA10

Class: DEG_APCC_DBOX_1

Location: 116:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5477

ASA_SCORE: 61.3778

COIL: 0.3991

CONS_SCORE: 0.5456

DSS_SCORE: 0.035

HELIX: 0.0103

FCONS_SCORE: 0.875

RIG_SCORE: 0.9142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I112M	TCGA-BA-5152	HNSC	TCGA	DRVKLFGIE	DEG_APCC_DBOX_1	0.2222
p.I112M	DO14393	HNSC	ICGC	DRVKLFGIE	DEG_APCC_DBOX_1	0.2222
p.V107M	TCGA-C5-A2LX	CESC	TCGA	DRVKLFGIE	DEG_APCC_DBOX_1	0.0833
p.V107M	TCGA-D8-A1Y1	BRCA	TCGA	DRVKLFGIE	DEG_APCC_DBOX_1	0.0833
p.V107M	DO1398	BRCA	ICGC	DRVKLFGIE	DEG_APCC_DBOX_1	0.0833
p.V107M	DO49004	CESC	ICGC	DRVKLFGIE	DEG_APCC_DBOX_1	0.0833
p.V107M	DO50970	LICA	ICGC	DRVKLFGIE	DEG_APCC_DBOX_1	0.0833
p.D129N	TCGA-C5-A902	CESC	TCGA	DRVKLFGIE	DEG_APCC_DBOX_1	0.1944
p.D129N	DO49916	CESC	ICGC	DRVKLFGIE	DEG_APCC_DBOX_1	0.1944
p.I123V	SIDM00333	Endometrial Carcinoma	GDSC	DRVKLFGIE	DEG_APCC_DBOX_1	0.5965
p.I123V	ACH-000988	Endometrial/Uterine Cancer	CCLE	DRVKLFGIE	DEG_APCC_DBOX_1	0.5965
p.I123V	MFE-319	endometrium	COSMIC	DRVKLFGIE	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5H3	Protocadherin gamma-A10	DEG_APCC_DBOX_1	116:124	DRVKLFGIE	APC,CDC20,FZR1	0.5477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons