DegronMD

Uniprot ID: Q15649

Source protein: Zinc finger HIT domain-containing protein 3

Source gene: ZNHIT3

Class: DEG_APCC_DBOX_1

Location: 85:93

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9804

ASA_SCORE: 80.6556

COIL: 0.5

CONS_SCORE: 0.7379

DSS_SCORE: 0.4327

HELIX: 0.47

FCONS_SCORE: 1.0423

RIG_SCORE: 0.7624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L101S	TCGA-06-5416	GBM	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.1111
p.L101S	DO10880	GBM	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.1111
p.D81G	TCGA-A4-7583	KIRP	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.2222
p.D81G	DO20870	KIRP	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.2222
p.R86I	TCGA-A5-A0G2	UCEC	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.8102
p.R86I	DO41235	UCEC	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.8102
p.K93N	TCGA-DF-A2KV	UCEC	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.5806
p.K93N	DO219771	UCEC	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.5806
p.S98T	TCGA-DI-A1BU	UCEC	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.1944
p.S98T	DO42023	UCEC	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.1944
p.S88F	TCGA-DK-A6B6	BLCA	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.7982
p.S88F	DO48576	BLCA	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.7982
p.L95V	TCGA-EY-A1G8	UCEC	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.2778
p.L95V	DO43578	UCEC	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.2778
p.Q90E	TCGA-MP-A4T2	LUAD	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.5633
p.Q90E	DO45378	LUAD	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.5633
p.Q90H	TCGA-VQ-A8P2	STAD	TCGA	DRVSLQNLK	DEG_APCC_DBOX_1	0.647
p.Q90H	DO51761	STAD	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.647
p.D81N	DO222753	MELA	ICGC	DRVSLQNLK	DEG_APCC_DBOX_1	0.2222
p.L78V	SIDM01588	Endometrial Carcinoma	GDSC	DRVSLQNLK	DEG_APCC_DBOX_1	0.1389
p.L78V	ACH-000993	Endometrial/Uterine Cancer	CCLE	DRVSLQNLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15649	Zinc finger HIT domain-containing protein 3	DEG_APCC_DBOX_1	85:93	DRVSLQNLK	APC,CDC20,FZR1	0.9804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons