DegronMD

Uniprot ID: Q9UFH2

Source protein: Dynein axonemal heavy chain 17

Source gene: DNAH17

Class: DEG_SCF_TRCP1_1

Location: 4184:4189

E3 ligase: BTRC

DEGRON score: 0.9297

ASA_SCORE: 71.7833

COIL: 0.9273

CONS_SCORE: 0.4177

DSS_SCORE: 0.5958

HELIX: 0.0513

FCONS_SCORE: 1.4299

RIG_SCORE: 0.6309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4199R	DO217867	GACA	ICGC	DSGAGT	DEG_SCF_TRCP1_1	0.0556
p.D4184N	SIDM01175	Other Sarcomas	GDSC	DSGAGT	DEG_SCF_TRCP1_1	0.6932
p.D4184N	SW684	soft_tissue	COSMIC	DSGAGT	DEG_SCF_TRCP1_1	0.6932
p.E4194K	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	DSGAGT	DEG_SCF_TRCP1_1	0.1944
p.E4194K	NCI-H1355	lung	COSMIC	DSGAGT	DEG_SCF_TRCP1_1	0.1944
p.D4179N	ACH-002309	Sarcoma	CCLE	DSGAGT	DEG_SCF_TRCP1_1	0.1944
p.D4179N	SW684	soft_tissue	COSMIC	DSGAGT	DEG_SCF_TRCP1_1	0.1944
p.E4189K	NCI-H1355	lung	COSMIC	DSGAGT	DEG_SCF_TRCP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UFH2	Dynein axonemal heavy chain 17	DEG_SCF_TRCP1_1	4184:4189	DSGAGT	BTRC	0.9297	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons