DegronMD

Uniprot ID: O00468

Source protein: Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

Source gene: AGRN

Class: DEG_SCF_TRCP1_1

Location: 1901:1907

E3 ligase: BTRC

DEGRON score: 0.9333

ASA_SCORE: 62.4857

COIL: 0.6991

CONS_SCORE: 0.4951

DSS_SCORE: 0.4608

HELIX: 0.2366

FCONS_SCORE: 1.0952

RIG_SCORE: 0.7105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1898H	TCGA-A6-5665	COAD	TCGA	DSGALHS	DEG_SCF_TRCP1_1	0.25
p.R1898H	DO9756	COAD	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.25
p.T1902M	TCGA-AX-A1CE	UCEC	TCGA	DSGALHS	DEG_SCF_TRCP1_1	0.7423
p.T1902M	DO42280	UCEC	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.7423
p.R1915L	TCGA-DA-A1I1	SKCM	TCGA	DSGALHS	DEG_SCF_TRCP1_1	0.1111
p.R1915L	DO37966	SKCM	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.1111
p.R1898C	TCGA-IB-7651	PAAD	TCGA	DSGALHS	DEG_SCF_TRCP1_1	0.25
p.R1898C	DO46657	PAAD	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.25
p.A1916V	TCGA-IB-7651	PAAD	TCGA	DSGALHS	DEG_SCF_TRCP1_1	0.0833
p.A1916V	DO46657	PAAD	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.0833
p.S1896R	DO222548	COCA	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.1944
p.S1896R	DO46386	OV	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.1944
p.A1912V	DO233280	GACA	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.1944
p.A1912V	SIDM00473	Oral Cavity Carcinoma	GDSC	DSGALHS	DEG_SCF_TRCP1_1	0.1944
p.L1907F	DO233885	GACA	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.6981
p.T1913M	DO41199	UCEC	ICGC	DSGALHS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00468	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment	DEG_SCF_TRCP1_1	1901:1907	DSGALHS	BTRC	0.9333	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons