DegronMD

Uniprot ID: O15504

Source protein: Nucleoporin NUP42

Source gene: NUP42

Class: DEG_SCF_TRCP1_1

Location: 84:89

E3 ligase: BTRC

DEGRON score: 0.9973

ASA_SCORE: 55.4

COIL: 0.865

CONS_SCORE: 0.4265

DSS_SCORE: 0.4904

HELIX: 0.0875

FCONS_SCORE: 0.8834

RIG_SCORE: 0.6235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D84G	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	DSGAST	DEG_SCF_TRCP1_1	0.7198
p.G94V	SIDM00778	Colorectal Carcinoma	GDSC	DSGAST	DEG_SCF_TRCP1_1	0.1944
p.S82Y	SIDM00999	Bladder Carcinoma	GDSC	DSGAST	DEG_SCF_TRCP1_1	0.7222
p.S82Y	SIDM00534	Colorectal Carcinoma	GDSC	DSGAST	DEG_SCF_TRCP1_1	0.7222
p.A87D	SIDM00999	Bladder Carcinoma	GDSC	DSGAST	DEG_SCF_TRCP1_1	0.6682

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15504	Nucleoporin NUP42	DEG_SCF_TRCP1_1	84:89	DSGAST	BTRC	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons