DegronMD

Uniprot ID: O00548

Source protein: Delta-like protein 1

Source gene: DLL1

Class: DEG_SCF_TRCP1_1

Location: 693:699

E3 ligase: BTRC

DEGRON score: 0.9944

ASA_SCORE: 66.7429

COIL: 0.854

CONS_SCORE: 0.2943

DSS_SCORE: 0.5537

HELIX: 0.062

FCONS_SCORE: 0.7625

RIG_SCORE: 0.627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K700N	TCGA-77-7335	LUSC	TCGA	DSGCSTS	DEG_SCF_TRCP1_1	0.3056
p.K700N	DO26707	LUSC	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.3056
p.S694L	TCGA-AJ-A3BG	UCEC	TCGA	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.S694L	TCGA-FD-A3B3	BLCA	TCGA	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.S694L	DO749	BLCA	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.S694L	DO42633	UCEC	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.S694L	SIDM00120	Prostate Carcinoma	GDSC	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.S694L	ACH-000979	Prostate Cancer	CCLE	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.S694L	DU-145	prostate	COSMIC	DSGCSTS	DEG_SCF_TRCP1_1	0.7667
p.R689I	TCGA-AX-A2HC	UCEC	TCGA	DSGCSTS	DEG_SCF_TRCP1_1	0.2222
p.R689I	DO41572	UCEC	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.2222
p.S706L	TCGA-BR-8680	STAD	TCGA	DSGCSTS	DEG_SCF_TRCP1_1	0.5833
p.S706L	DO47769	STAD	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.5833
p.Q705H	DO1121	BRCA	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.1667
p.V709I	DO229389	BTCA	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.0556
p.P692S	DO222418	MELA	ICGC	DSGCSTS	DEG_SCF_TRCP1_1	0.3056
p.S697L	SIDM01722	Non-Cancerous	GDSC	DSGCSTS	DEG_SCF_TRCP1_1	0.6556
p.S697L	SIDM00174	Head and Neck Carcinoma	GDSC	DSGCSTS	DEG_SCF_TRCP1_1	0.6556
p.S697L	ACH-002213	Head and Neck Cancer	CCLE	DSGCSTS	DEG_SCF_TRCP1_1	0.6556
p.S697L	ACH-002343	Non-Cancerous	CCLE	DSGCSTS	DEG_SCF_TRCP1_1	0.6556
p.D701Y	SIDM01186	Breast Carcinoma	GDSC	DSGCSTS	DEG_SCF_TRCP1_1	0.2778
p.D701Y	ACH-000554	Breast Cancer	CCLE	DSGCSTS	DEG_SCF_TRCP1_1	0.2778
p.D701Y	UACC-893	breast	COSMIC	DSGCSTS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00548	Delta-like protein 1	DEG_SCF_TRCP1_1	693:699	DSGCSTS	BTRC	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons