DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: DEG_SCF_TRCP1_1

Location: 724:730

E3 ligase: BTRC

DEGRON score: 0.8201

ASA_SCORE: 25.1286

COIL: 0.6509

CONS_SCORE: 0.3533

DSS_SCORE: 0.5102

HELIX: 0.1126

FCONS_SCORE: 1.0113

RIG_SCORE: 0.6663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R740L	TCGA-09-2044	OV	TCGA	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740L	DO28923	OV	ICGC	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	TCGA-AZ-4315	COAD	TCGA	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	DO8842	COAD	ICGC	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	SIDM00680	Colorectal Carcinoma	GDSC	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	SIDM00318	Kidney Carcinoma	GDSC	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	ACH-000484	Kidney Cancer	CCLE	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	ACH-000957	Colon/Colorectal Cancer	CCLE	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	LS-180	large_intestine	COSMIC	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R740W	VMRC-RCW	kidney	COSMIC	DSGCYES	DEG_SCF_TRCP1_1	0.0556
p.R723Q	TCGA-EO-A22X	UCEC	TCGA	DSGCYES	DEG_SCF_TRCP1_1	0.3056
p.R723Q	DO43907	UCEC	ICGC	DSGCYES	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SCF_TRCP1_1	724:730	DSGCYES	BTRC	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons