DegronMD

Uniprot ID: Q9Y2G2

Source protein: Caspase recruitment domain-containing protein 8

Source gene: CARD8

Class: DEG_SCF_TRCP1_1

Location: 129:135

E3 ligase: BTRC

DEGRON score: 0.9452

ASA_SCORE: 70.8714

COIL: 0.7899

CONS_SCORE: 0.849

DSS_SCORE: 0.6541

HELIX: 0.1461

FCONS_SCORE: 1.0241

RIG_SCORE: 0.675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E137D	TCGA-AX-A0J0	UCEC	TCGA	DSGDICS	DEG_SCF_TRCP1_1	0.2778
p.E137D	TCGA-EO-A22R	UCEC	TCGA	DSGDICS	DEG_SCF_TRCP1_1	0.2778
p.G131V	TCGA-ER-A19G	SKCM	TCGA	DSGDICS	DEG_SCF_TRCP1_1	0.7532
p.V120I	DO233245	GACA	ICGC	DSGDICS	DEG_SCF_TRCP1_1	0.0833
p.A144V	DO230659	LAML	ICGC	DSGDICS	DEG_SCF_TRCP1_1	0.0833
p.A144V	DO231140	LAML	ICGC	DSGDICS	DEG_SCF_TRCP1_1	0.0833
p.P135H	DO38443	STAD	ICGC	DSGDICS	DEG_SCF_TRCP1_1	0.7694
p.N128H	DO41020	UCEC	ICGC	DSGDICS	DEG_SCF_TRCP1_1	0.3056
p.P135S	MCC26	skin	COSMIC	DSGDICS	DEG_SCF_TRCP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2G2	Caspase recruitment domain-containing protein 8	DEG_SCF_TRCP1_1	129:135	DSGDICS	BTRC	0.9452	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons