DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGDSGS
Uniprot ID:
Q9H706
Source protein:
GRB2-associated and regulator of MAPK protein 1
Source gene:
GAREM1
Class:
DEG_SCF_TRCP1_1
Location:
425:431
E3 ligase:
BTRC
DEGRON score:
0.9372
ASA_SCORE:
69.5714
COIL:
0.8743
CONS_SCORE:
0.2074
DSS_SCORE:
0.5145
HELIX:
0.0841
FCONS_SCORE:
0.8328
RIG_SCORE:
0.6197
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P417S
SIDM01692
T-Cell Non-Hodgkin's Lymphoma
GDSC
DSGDSGS
DEG_SCF_TRCP1_1
0.1111
p.G430W
SIDM01387
Small Cell Lung Carcinoma
GDSC
DSGDSGS
DEG_SCF_TRCP1_1
0.6714
Drug responses associated with GAREM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGDSGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H706
GRB2-associated and regulator of MAPK protein 1
DEG_SCF_TRCP1_1
425:431
DSGDSGS
BTRC
0.9372
More...