DegronMD

Uniprot ID: Q8IVF2

Source protein: Protein AHNAK2

Source gene: AHNAK2

Class: DEG_SCF_TRCP1_1

Location: 91:97

E3 ligase: BTRC

DEGRON score: 0.9524

ASA_SCORE: 88.4857

COIL: 0.8369

CONS_SCORE: 0.3836

DSS_SCORE: 0.4114

HELIX: 0.1187

FCONS_SCORE: 0.97

RIG_SCORE: 0.6841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R84Q	TCGA-85-A50M	LUSC	TCGA	DSGDSRT	DEG_SCF_TRCP1_1	0.1389
p.R84Q	DO45546	LUSC	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.1389
p.V107A	TCGA-AB-2833	LAML	TCGA	DSGDSRT	DEG_SCF_TRCP1_1	0.0556
p.V107A	DO21679	LAML	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.0556
p.R96Q	TCGA-B5-A3FA	UCEC	TCGA	DSGDSRT	DEG_SCF_TRCP1_1	0.6218
p.R96Q	DO52402	UCEC	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.6218
p.S86F	TCGA-W3-AA1V	SKCM	TCGA	DSGDSRT	DEG_SCF_TRCP1_1	0.1944
p.S86F	DO51276	SKCM	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.1944
p.R103H	DO228544	GACA	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.1667
p.R103H	SIDM01612	Endometrial Carcinoma	GDSC	DSGDSRT	DEG_SCF_TRCP1_1	0.1667
p.L85F	DO14910	HNSC	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.1667
p.L85F	DO37579	SKCM	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.1667
p.H86Q	DO228971	LICA	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.1944
p.V90A	DO50118	STAD	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.3056
p.A98V	DO38288	STAD	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.3056
p.S94I	DO43859	UCEC	ICGC	DSGDSRT	DEG_SCF_TRCP1_1	0.7341
p.A81S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DSGDSRT	DEG_SCF_TRCP1_1	0.0556
p.A81S	ACH-001127	Leukemia	CCLE	DSGDSRT	DEG_SCF_TRCP1_1	0.0556
p.A81S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDSRT	DEG_SCF_TRCP1_1	0.0556
p.D91N	SIDM01619	Endometrial Carcinoma	GDSC	DSGDSRT	DEG_SCF_TRCP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF2	Protein AHNAK2	DEG_SCF_TRCP1_1	91:97	DSGDSRT	BTRC	0.9524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons