DegronMD

Uniprot ID: Q5XG99

Source protein: LysM and putative peptidoglycan-binding domain-containing protein 4

Source gene: LYSMD4

Class: DEG_SCF_TRCP1_1

Location: 34:39

E3 ligase: BTRC

DEGRON score: 0.9237

ASA_SCORE: 74.6667

COIL: 0.854

CONS_SCORE: 0.3722

DSS_SCORE: 0.6102

HELIX: 0.1183

FCONS_SCORE: 0.9245

RIG_SCORE: 0.5443

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A26T	TCGA-BR-8361	STAD	TCGA	DSGDSS	DEG_SCF_TRCP1_1	0.1111
p.S31Y	TCGA-IE-A4EJ	SARC	TCGA	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.S31Y	DO220155	SARC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.V25I	DO48566	BLCA	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.0833
p.V25I	ACH-001610	Brain Cancer	CCLE	DSGDSS	DEG_SCF_TRCP1_1	0.0833
p.G46A	DO5074	BRCA	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.1389
p.R28S	DO10172	COAD	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.1667
p.R49W	DO10132	COAD	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.0556
p.A31V	DO227999	COCA	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.A31V	DO229003	COCA	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.A31V	DO228941	LICA	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.A31V	DO230993	LUSC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.A31G	DO234363	ESAD	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.D34G	DO44440	HNSC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.7198
p.G42S	DO48606	LGG	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.A26V	DO222521	MELA	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.1111
p.D27A	DO51407	PRAD	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.1389
p.R45H	DO40843	UCEC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.1667
p.T33A	DO42023	UCEC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.3056
p.V47A	DO42023	UCEC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.1111
p.R49Q	DO52419	UCEC	ICGC	DSGDSS	DEG_SCF_TRCP1_1	0.0556
p.T41M	SIDM00217	Colorectal Carcinoma	GDSC	DSGDSS	DEG_SCF_TRCP1_1	0.2778
p.T41M	SNU-1040	large_intestine	COSMIC	DSGDSS	DEG_SCF_TRCP1_1	0.2778
p.S31F	SIDM00248	Gastric Carcinoma	GDSC	DSGDSS	DEG_SCF_TRCP1_1	0.25
p.G36E	ACH-001275	Sarcoma	CCLE	DSGDSS	DEG_SCF_TRCP1_1	0.7199
p.P38L	SW900	lung	COSMIC	DSGDSS	DEG_SCF_TRCP1_1	0.7582
p.R35K	NCI-H1770	lung	COSMIC	DSGDSS	DEG_SCF_TRCP1_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5XG99	LysM and putative peptidoglycan-binding domain-containing protein 4	DEG_SCF_TRCP1_1	34:39	DSGDSS	BTRC	0.9237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons