DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGEDS
Uniprot ID:
Q15018
Source protein:
BRISC complex subunit Abraxas 2
Source gene:
ABRAXAS2
Class:
DEG_SCF_TRCP1_1
Location:
367:372
E3 ligase:
BTRC
DEGRON score:
0.888
ASA_SCORE:
89.2333
COIL:
0.9567
CONS_SCORE:
0.313
DSS_SCORE:
0.839
HELIX:
0.0315
FCONS_SCORE:
0.9353
RIG_SCORE:
0.5361
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ABRAXAS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGEDS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15018
BRISC complex subunit Abraxas 2
DEG_SCF_TRCP1_1
367:372
DSGEDS
BTRC
0.888
More...