DegronMD

Uniprot ID: Q9P1A2

Source protein: Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

Source gene: PPP4R1L

Class: DEG_SCF_TRCP1_1

Location: 298:303

E3 ligase: BTRC

DEGRON score: 0.9896

ASA_SCORE: 69.9833

COIL: 0.8417

CONS_SCORE: 0.4285

DSS_SCORE: 0.5203

HELIX: 0.1128

FCONS_SCORE: 1.1417

RIG_SCORE: 0.6481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S305C	DO229340	BTCA	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.2778
p.N313T	DO233081	GACA	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.0556
p.S289R	DO233951	GACA	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.0833
p.N313K	DO228948	LICA	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.0556
p.P292T	DO229032	LICA	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.1667
p.P308S	DO229446	SKCA	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.1944
p.D298N	DO43506	UCEC	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.6932
p.G304D	DO43506	UCEC	ICGC	DSGFAS	DEG_SCF_TRCP1_1	0.3056
p.P308L	ACH-000158	Lymphoma	CCLE	DSGFAS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SCF_TRCP1_1	298:303	DSGFAS	BTRC	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons