DegronMD

Uniprot ID: Q8TAF3

Source protein: WD repeat-containing protein 48

Source gene: WDR48

Class: DEG_SCF_TRCP1_1

Location: 532:537

E3 ligase: BTRC

DEGRON score: 0.5647

ASA_SCORE: 67.2833

COIL: 0.8038

CONS_SCORE: 0.4574

DSS_SCORE: 0.2336

HELIX: 0.045

FCONS_SCORE: 1.0657

RIG_SCORE: 0.7258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E536D	TCGA-AP-A1DK	UCEC	TCGA	DSGGET	DEG_SCF_TRCP1_1	0.5647
p.S533Y	TCGA-B5-A3FA	UCEC	TCGA	DSGGET	DEG_SCF_TRCP1_1	0.712
p.R523C	TCGA-EE-A29S	SKCM	TCGA	DSGGET	DEG_SCF_TRCP1_1	0.0833
p.R531L	TCGA-L5-A4OJ	ESCA	TCGA	DSGGET	DEG_SCF_TRCP1_1	0.3056
p.M540L	SIDM01175	Other Sarcomas	GDSC	DSGGET	DEG_SCF_TRCP1_1	0.25
p.M540L	ACH-002309	Sarcoma	CCLE	DSGGET	DEG_SCF_TRCP1_1	0.25
p.M540L	SW684	soft_tissue	COSMIC	DSGGET	DEG_SCF_TRCP1_1	0.25
p.E538Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGET	DEG_SCF_TRCP1_1	0.3056
p.E538Q	ACH-002253	Lymphoma	CCLE	DSGGET	DEG_SCF_TRCP1_1	0.3056
p.E538Q	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGET	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAF3	WD repeat-containing protein 48	DEG_SCF_TRCP1_1	532:537	DSGGET	BTRC	0.5647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons