DegronMD

Uniprot ID: O15209

Source protein: Zinc finger and BTB domain-containing protein 22

Source gene: ZBTB22

Class: DEG_SCF_TRCP1_1

Location: 398:403

E3 ligase: BTRC

DEGRON score: 0.983

ASA_SCORE: 64.3833

COIL: 0.9168

CONS_SCORE: 0.4365

DSS_SCORE: 0.7091

HELIX: 0.0252

FCONS_SCORE: 1.1259

RIG_SCORE: 0.5101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S405F	TCGA-33-4589	LUSC	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.2778
p.S405F	DO26623	LUSC	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.2778
p.G389S	TCGA-AP-A1DK	UCEC	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.0833
p.G389S	DO42033	UCEC	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.0833
p.A394G	TCGA-AZ-4614	COAD	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.2222
p.A394G	DO10012	COAD	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.2222
p.S406F	TCGA-CN-6022	HNSC	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.25
p.S406F	TCGA-EE-A2MI	SKCM	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.25
p.S406F	DO14293	HNSC	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.25
p.S406F	DO37531	SKCM	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.25
p.S410C	TCGA-EE-A2GJ	SKCM	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.1389
p.S410C	DO37746	SKCM	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.1389
p.S399L	TCGA-EE-A3J7	SKCM	TCGA	DSGGPT	DEG_SCF_TRCP1_1	0.7667
p.S399L	DO48770	SKCM	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.7667
p.G400R	DO233782	GACA	ICGC	DSGGPT	DEG_SCF_TRCP1_1	0.7568
p.P404L	SIDM01175	Other Sarcomas	GDSC	DSGGPT	DEG_SCF_TRCP1_1	0.3056
p.P404L	ACH-002309	Sarcoma	CCLE	DSGGPT	DEG_SCF_TRCP1_1	0.3056
p.P404L	SW684	soft_tissue	COSMIC	DSGGPT	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15209	Zinc finger and BTB domain-containing protein 22	DEG_SCF_TRCP1_1	398:403	DSGGPT	BTRC	0.983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons