DegronMD

Uniprot ID: Q9HCN3

Source protein: Post-GPI attachment to proteins factor 6

Source gene: PGAP6

Class: DEG_SCF_TRCP1_1

Location: 395:401

E3 ligase: BTRC

DEGRON score: 0.8719

ASA_SCORE: 26.8

COIL: 0.4191

CONS_SCORE: 0.5818

DSS_SCORE: 0.3702

HELIX: 0.0149

FCONS_SCORE: 1.5684

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R387Q	SIDM01943	Colorectal Carcinoma	GDSC	DSGGSLT	DEG_SCF_TRCP1_1	0.1111
p.S403T	SIDM00040	Gastric Carcinoma	GDSC	DSGGSLT	DEG_SCF_TRCP1_1	0.2778
p.G398D	SIDM01182	Bladder Carcinoma	GDSC	DSGGSLT	DEG_SCF_TRCP1_1	0.6087
p.R387W	SIDM00217	Colorectal Carcinoma	GDSC	DSGGSLT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCN3	Post-GPI attachment to proteins factor 6	DEG_SCF_TRCP1_1	395:401	DSGGSLT	BTRC	0.8719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons