DegronMD

Uniprot ID: Q13563

Source protein: Polycystin-2

Source gene: PKD2

Class: DEG_SCF_TRCP1_1

Location: 819:824

E3 ligase: BTRC

DEGRON score: 0.6209

ASA_SCORE: 81.6167

COIL: 0.8737

CONS_SCORE: 0.2427

DSS_SCORE: 0.7143

HELIX: 0.1077

FCONS_SCORE: 0.5848

RIG_SCORE: 0.5609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D810N	TCGA-05-4410	LUAD	TCGA	DSGHSS	DEG_SCF_TRCP1_1	0.0833
p.S812F	TCGA-34-5231	LUSC	TCGA	DSGHSS	DEG_SCF_TRCP1_1	0.5833
p.G821R	TCGA-AA-A01R	COAD	TCGA	DSGHSS	DEG_SCF_TRCP1_1	0.7568
p.G821R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGHSS	DEG_SCF_TRCP1_1	0.7568
p.G833D	TCGA-IS-A3K7	SARC	TCGA	DSGHSS	DEG_SCF_TRCP1_1	0.0833
p.D817N	TCGA-LL-A740	BRCA	TCGA	DSGHSS	DEG_SCF_TRCP1_1	0.2778
p.D816N	TCGA-NJ-A4YF	LUAD	TCGA	DSGHSS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13563	Polycystin-2	DEG_SCF_TRCP1_1	819:824	DSGHSS	BTRC	0.6209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons