DegronMD

Uniprot ID: P18848

Source protein: Cyclic AMP-dependent transcription factor ATF-4

Source gene: ATF4

Class: DEG_SCF_TRCP1_1

Location: 218:224

E3 ligase: BTRC

DEGRON score: 0.9897

ASA_SCORE: 75.5143

COIL: 0.877

CONS_SCORE: 0.5618

DSS_SCORE: 0.632

HELIX: 0.0376

FCONS_SCORE: 0.9279

RIG_SCORE: 0.6762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G220C	TCGA-77-8153	LUSC	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.76
p.G220C	DO45426	LUSC	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.76
p.L229V	TCGA-C5-A1MK	CESC	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.1944
p.L229V	DO6290	CESC	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.1944
p.L229M	TCGA-CN-A63T	HNSC	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.1944
p.L229M	DO49040	HNSC	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.1944
p.P225Q	TCGA-D3-A2JO	SKCM	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.3056
p.P225Q	DO47619	SKCM	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.3056
p.S215L	TCGA-D3-A51R	SKCM	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.6944
p.S215L	DO47480	SKCM	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.6944
p.P214L	TCGA-D3-A8GI	SKCM	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.2222
p.P214L	DO50901	LICA	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.2222
p.P214L	DO50284	SKCM	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.2222
p.S227F	TCGA-EE-A3J7	SKCM	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.25
p.S227F	DO48770	SKCM	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.25
p.E211K	TCGA-FR-A728	SKCM	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.1389
p.E211K	DO48550	SKCM	ICGC	DSGICMS	DEG_SCF_TRCP1_1	0.1389
p.T213I	TCGA-OR-A5JD	ACC	TCGA	DSGICMS	DEG_SCF_TRCP1_1	0.1944
p.I208M	SIDM00622	Glioblastoma	GDSC	DSGICMS	DEG_SCF_TRCP1_1	0.0556
p.I208M	SIDM01323	Oral Cavity Carcinoma	GDSC	DSGICMS	DEG_SCF_TRCP1_1	0.0556
p.S219T	SIDM01613	Colorectal Carcinoma	GDSC	DSGICMS	DEG_SCF_TRCP1_1	0.8227
p.S219T	ACH-000199	Non-Cancerous	CCLE	DSGICMS	DEG_SCF_TRCP1_1	0.8227
p.I208V	ACH-001421	Eye Cancer	CCLE	DSGICMS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SCF_TRCP1_1	218:224	DSGICMS	BTRC	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons