DegronMD

Uniprot ID: O75309

Source protein: Cadherin-16

Source gene: CDH16

Class: DEG_SCF_TRCP1_1

Location: 60:65

E3 ligase: BTRC

DEGRON score: 0.8546

ASA_SCORE: 72.15

COIL: 0.7357

CONS_SCORE: 0.4182

DSS_SCORE: 0.5066

HELIX: 0.0535

FCONS_SCORE: 0.7796

RIG_SCORE: 0.6349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D72N	TCGA-AA-A010	COAD	TCGA	DSGKAT	DEG_SCF_TRCP1_1	0.1389
p.G62D	TCGA-AJ-A3EL	UCEC	TCGA	DSGKAT	DEG_SCF_TRCP1_1	0.7198
p.G62D	DO41542	UCEC	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.7198
p.V56M	TCGA-DB-A4XG	LGG	TCGA	DSGKAT	DEG_SCF_TRCP1_1	0.2222
p.V56M	DO44583	LGG	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.2222
p.E69Q	DO44052	BLCA	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.2222
p.F67L	DO465	BLCA	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.2778
p.R54W	DO234335	ESAD	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.1667
p.R54Q	DO48228	ESCA	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.1667
p.R54Q	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKAT	DEG_SCF_TRCP1_1	0.1667
p.D74N	DO233848	GACA	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.0833
p.T59N	DO229015	LICA	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.3056
p.R73Q	DO23822	LUAD	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.1111
p.R60K	DO51273	SKCM	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.7237
p.E75K	DO219503	SKCM	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.0556
p.L66H	DO229240	THCA	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.3056
p.R60M	DO42280	UCEC	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.8632
p.A70S	DO43755	UCEC	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.1944
p.P61H	DO41361	UCEC	ICGC	DSGKAT	DEG_SCF_TRCP1_1	0.7694
p.G62R	SIDM01141	Ovarian Carcinoma	GDSC	DSGKAT	DEG_SCF_TRCP1_1	0.7568
p.G62R	ACH-000291	Ovarian Cancer	CCLE	DSGKAT	DEG_SCF_TRCP1_1	0.7568
p.G62R	OV-90	ovary	COSMIC	DSGKAT	DEG_SCF_TRCP1_1	0.7568
p.E66K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGKAT	DEG_SCF_TRCP1_1	0.3056
p.E66K	ACH-002256	Leukemia	CCLE	DSGKAT	DEG_SCF_TRCP1_1	0.3056
p.E66K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKAT	DEG_SCF_TRCP1_1	0.3056
p.A51T	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DSGKAT	DEG_SCF_TRCP1_1	0.0833
p.T65S	SIDM01617	Endometrial Carcinoma	GDSC	DSGKAT	DEG_SCF_TRCP1_1	0.6005
p.T65S	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGKAT	DEG_SCF_TRCP1_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75309	Cadherin-16	DEG_SCF_TRCP1_1	60:65	DSGKAT	BTRC	0.8546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKAT

Degron related mutations and impact score

Drug responses associated with CDH16 mutations

All proteins holding degron of DSGKAT