DegronMD

Uniprot ID: Q68DI1

Source protein: Zinc finger protein 776

Source gene: ZNF776

Class: DEG_SCF_TRCP1_1

Location: 240:246

E3 ligase: BTRC

DEGRON score: 0.9633

ASA_SCORE: 61.5

COIL: 0.6436

CONS_SCORE: 0.576

DSS_SCORE: 0.429

HELIX: 0.1717

FCONS_SCORE: 1.02

RIG_SCORE: 0.6832

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S241Y	TCGA-D1-A103	UCEC	TCGA	DSGKFTS	DEG_SCF_TRCP1_1	0.712
p.S241Y	DO42312	UCEC	ICGC	DSGKFTS	DEG_SCF_TRCP1_1	0.712
p.F244S	SIDM00211	B-Lymphoblastic Leukemia	GDSC	DSGKFTS	DEG_SCF_TRCP1_1	0.6871
p.F244S	ACH-002209	Leukemia	CCLE	DSGKFTS	DEG_SCF_TRCP1_1	0.6871
p.F244S	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKFTS	DEG_SCF_TRCP1_1	0.6871
p.F244C	TCGA-ZB-A96M	THYM	TCGA	DSGKFTS	DEG_SCF_TRCP1_1	0.5996
p.S248R	DO222755	COCA	ICGC	DSGKFTS	DEG_SCF_TRCP1_1	0.2778
p.G234R	DO233106	GACA	ICGC	DSGKFTS	DEG_SCF_TRCP1_1	0.1667
p.H254N	TCGA-19-5956	GBM	TCGA	DSGKFTS	DEG_SCF_TRCP1_1	0.1111
p.H254N	DO13863	GBM	ICGC	DSGKFTS	DEG_SCF_TRCP1_1	0.1111
p.R232T	TCGA-25-2398	OV	TCGA	DSGKFTS	DEG_SCF_TRCP1_1	0.1111
p.R232T	DO31250	OV	ICGC	DSGKFTS	DEG_SCF_TRCP1_1	0.1111

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DI1	Zinc finger protein 776	DEG_SCF_TRCP1_1	240:246	DSGKFTS	BTRC	0.9633	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons