DegronMD

Uniprot ID: Q8WUY3

Source protein: Protein prune homolog 2

Source gene: PRUNE2

Class: DEG_SCF_TRCP1_1

Location: 427:432

E3 ligase: BTRC

DEGRON score: 0.8818

ASA_SCORE: 64.1833

COIL: 0.7277

CONS_SCORE: 0.6605

DSS_SCORE: 0.5038

HELIX: 0.0738

FCONS_SCORE: 1.0791

RIG_SCORE: 0.6972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D427E	TCGA-55-5899	LUAD	TCGA	DSGLAT	DEG_SCF_TRCP1_1	0.6758
p.G429R	TCGA-69-7974	LUAD	TCGA	DSGLAT	DEG_SCF_TRCP1_1	0.7568
p.R437C	TCGA-AP-A1DK	UCEC	TCGA	DSGLAT	DEG_SCF_TRCP1_1	0.1944
p.P426Q	TCGA-EE-A2MG	SKCM	TCGA	DSGLAT	DEG_SCF_TRCP1_1	0.3056
p.T432I	TCGA-GN-A266	SKCM	TCGA	DSGLAT	DEG_SCF_TRCP1_1	0.7078
p.A436V	DO223703	COAD	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2222
p.A436V	DO43891	UCEC	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2222
p.N425H	DO233227	GACA	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2778
p.T427K	DO14702	HNSC	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.7306
p.W441C	DO45431	LUSC	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.0833
p.G424E	DO222875	MELA	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.25
p.A434T	DO28050	OV	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2778
p.N425Y	DO37679	SKCM	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2778
p.P432L	DO37671	SKCM	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.7582
p.P437L	DO37881	SKCM	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.1944
p.P439T	DO40190	THCA	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.1389
p.A434D	DO41758	UCEC	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2778
p.E421D	DO41542	UCEC	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.1667
p.N425T	DO41235	UCEC	ICGC	DSGLAT	DEG_SCF_TRCP1_1	0.2778
p.T432N	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGLAT	DEG_SCF_TRCP1_1	0.7055
p.T417I	NBsusSR	autonomic_ganglia	COSMIC	DSGLAT	DEG_SCF_TRCP1_1	0.0556
p.T417I	KYSE-140	oesophagus	COSMIC	DSGLAT	DEG_SCF_TRCP1_1	0.0556
p.T417I	TE-11	oesophagus	COSMIC	DSGLAT	DEG_SCF_TRCP1_1	0.0556
p.T427A	MZ7-mel	skin	COSMIC	DSGLAT	DEG_SCF_TRCP1_1	0.7139
p.D428H	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLAT	DEG_SCF_TRCP1_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUY3	Protein prune homolog 2	DEG_SCF_TRCP1_1	427:432	DSGLAT	BTRC	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons