DegronMD

Uniprot ID: Q92538

Source protein: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Source gene: GBF1

Class: DEG_SCF_TRCP1_1

Location: 291:297

E3 ligase: BTRC

DEGRON score: 0.5614

ASA_SCORE: 70.4571

COIL: 0.6707

CONS_SCORE: 0.213

DSS_SCORE: 0.5905

HELIX: 0.1656

FCONS_SCORE: 0.9444

RIG_SCORE: 0.6376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S289C	TCGA-EY-A1GS	UCEC	TCGA	DSGLEFS	DEG_SCF_TRCP1_1	0.2778
p.S289C	DO43162	UCEC	ICGC	DSGLEFS	DEG_SCF_TRCP1_1	0.2778
p.Q299K	TCGA-FS-A1ZQ	SKCM	TCGA	DSGLEFS	DEG_SCF_TRCP1_1	0.2778
p.Q299K	DO37442	SKCM	ICGC	DSGLEFS	DEG_SCF_TRCP1_1	0.2778
p.S287N	DO233148	GACA	ICGC	DSGLEFS	DEG_SCF_TRCP1_1	0.2222
p.V286F	SIDM00850	Gastric Carcinoma	GDSC	DSGLEFS	DEG_SCF_TRCP1_1	0.1944
p.V286F	ACH-000880	Gastric Cancer	CCLE	DSGLEFS	DEG_SCF_TRCP1_1	0.1944
p.V286F	AGS	stomach	COSMIC	DSGLEFS	DEG_SCF_TRCP1_1	0.1944
p.S292G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGLEFS	DEG_SCF_TRCP1_1	0.8104
p.S292G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLEFS	DEG_SCF_TRCP1_1	0.8104

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SCF_TRCP1_1	291:297	DSGLEFS	BTRC	0.5614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons