DegronMD

Uniprot ID: Q96P50

Source protein: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Source gene: ACAP3

Class: DEG_SCF_TRCP1_1

Location: 609:615

E3 ligase: BTRC

DEGRON score: 0.7144

ASA_SCORE: 63.2143

COIL: 0.8733

CONS_SCORE: 0.22

DSS_SCORE: 0.5371

HELIX: 0.084

FCONS_SCORE: 0.9679

RIG_SCORE: 0.5535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S620T	TCGA-A5-A1OF	UCEC	TCGA	DSGLGGS	DEG_SCF_TRCP1_1	0.1944
p.S620T	DO42568	UCEC	ICGC	DSGLGGS	DEG_SCF_TRCP1_1	0.1944
p.A599T	TCGA-E7-A7DV	BLCA	TCGA	DSGLGGS	DEG_SCF_TRCP1_1	0.0556
p.P603T	SIDM00511	Small Cell Lung Carcinoma	GDSC	DSGLGGS	DEG_SCF_TRCP1_1	0.1667
p.P603T	COR-L279	lung	COSMIC	DSGLGGS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P50	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3	DEG_SCF_TRCP1_1	609:615	DSGLGGS	BTRC	0.7144	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons