DegronMD

Uniprot ID: P46937

Source protein: Transcriptional coactivator YAP1

Source gene: YAP1

Class: DEG_SCF_TRCP1_1

Location: 399:405

E3 ligase: BTRC

DEGRON score: 0.9899

ASA_SCORE: 60.3571

COIL: 0.6921

CONS_SCORE: 0.6475

DSS_SCORE: 0.5959

HELIX: 0.1509

FCONS_SCORE: 1.0168

RIG_SCORE: 0.6172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T398A	TCGA-AP-A051	UCEC	TCGA	DSGLSMS	DEG_SCF_TRCP1_1	0.75
p.T398A	DO42673	UCEC	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.75
p.H392N	TCGA-EE-A2GT	SKCM	TCGA	DSGLSMS	DEG_SCF_TRCP1_1	0.1389
p.H392N	DO37946	SKCM	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.1389
p.E396D	TCGA-HE-7130	KIRP	TCGA	DSGLSMS	DEG_SCF_TRCP1_1	0.25
p.E396D	DO20776	KIRP	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.25
p.P413Q	TCGA-KO-8408	KICH	TCGA	DSGLSMS	DEG_SCF_TRCP1_1	0.1111
p.P413Q	DO220562	KICH	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.1111
p.L402P	DO223566	CLLE	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.6471
p.R394Q	DO234263	ESAD	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.1944
p.V409F	DO229019	LICA	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.2222
p.S397I	DO229035	LICA	ICGC	DSGLSMS	DEG_SCF_TRCP1_1	0.7222
p.G413A	BHY	upper_aerodigestive_tract	COSMIC	DSGLSMS	DEG_SCF_TRCP1_1	0.1111
p.R390C	SNU-1040	large_intestine	COSMIC	DSGLSMS	DEG_SCF_TRCP1_1	0.5278
p.R406C	SNU-1040	large_intestine	COSMIC	DSGLSMS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46937	Transcriptional coactivator YAP1	DEG_SCF_TRCP1_1	399:405	DSGLSMS	BTRC	0.9899	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons