DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGLTGS
Uniprot ID:
Q9Y592
Source protein:
Centrosomal protein of 83 kDa
Source gene:
CEP83
Class:
DEG_SCF_TRCP1_1
Location:
21:27
E3 ligase:
BTRC
DEGRON score:
0.9664
ASA_SCORE:
72.7286
COIL:
0.7594
CONS_SCORE:
0.8893
DSS_SCORE:
0.5962
HELIX:
0.2196
FCONS_SCORE:
0.9952
RIG_SCORE:
0.6267
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R23C
DMS-79
lung
COSMIC
DSGLTGS
DEG_SCF_TRCP1_1
0.8301
p.E13G
SNU-1040
large_intestine
COSMIC
DSGLTGS
DEG_SCF_TRCP1_1
0.1111
Drug responses associated with CEP83 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGLTGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y592
Centrosomal protein of 83 kDa
DEG_SCF_TRCP1_1
21:27
DSGLTGS
BTRC
0.9664
More...