DegronMD

Uniprot ID: Q9P2E8

Source protein: E3 ubiquitin-protein ligase MARCHF4

Source gene: MARCHF4

Class: DEG_SCF_TRCP1_1

Location: 155:160

E3 ligase: BTRC

DEGRON score: 0.601

ASA_SCORE: 95.25

COIL: 0.9187

CONS_SCORE: 0.4252

DSS_SCORE: 0.1529

HELIX: 0.0555

FCONS_SCORE: 0.8899

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E145K	SIDM01306	Colorectal Carcinoma	GDSC	DSGMRT	DEG_SCF_TRCP1_1	0.0556
p.L154F	SIDM00545	Melanoma	GDSC	DSGMRT	DEG_SCF_TRCP1_1	0.3056
p.L150P	SIDM01247	Burkitt's Lymphoma	GDSC	DSGMRT	DEG_SCF_TRCP1_1	0.1944
p.R147C	SIDM00032	Bladder Carcinoma	GDSC	DSGMRT	DEG_SCF_TRCP1_1	0.1111
p.R164C	SIDM01394	Kidney Carcinoma	GDSC	DSGMRT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2E8	E3 ubiquitin-protein ligase MARCHF4	DEG_SCF_TRCP1_1	155:160	DSGMRT	BTRC	0.601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons