DegronMD

Uniprot ID: Q9UNS2

Source protein: COP9 signalosome complex subunit 3

Source gene: COPS3

Class: DEG_SCF_TRCP1_1

Location: 414:420

E3 ligase: BTRC

DEGRON score: 0.9708

ASA_SCORE: 102.5286

COIL: 0.949

CONS_SCORE: 0.3541

DSS_SCORE: 0.8707

HELIX: 0.0401

FCONS_SCORE: 0.8543

RIG_SCORE: 0.5597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S415L	TCGA-XF-A9T8	BLCA	TCGA	DSGNKPS	DEG_SCF_TRCP1_1	0.8778
p.S421I	DO231031	LUSC	ICGC	DSGNKPS	DEG_SCF_TRCP1_1	0.75
p.G416R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGNKPS	DEG_SCF_TRCP1_1	0.7568
p.G416R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGNKPS	DEG_SCF_TRCP1_1	0.7568
p.G416R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNKPS	DEG_SCF_TRCP1_1	0.7568
p.S421N	SIDM01450	Gastric Carcinoma	GDSC	DSGNKPS	DEG_SCF_TRCP1_1	0.75
p.E412D	SW156	kidney	COSMIC	DSGNKPS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNS2	COP9 signalosome complex subunit 3	DEG_SCF_TRCP1_1	414:420	DSGNKPS	BTRC	0.9708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons