DegronMD

Uniprot ID: Q8WUY3

Source protein: Protein prune homolog 2

Source gene: PRUNE2

Class: DEG_SCF_TRCP1_1

Location: 2650:2656

E3 ligase: BTRC

DEGRON score: 0.9934

ASA_SCORE: 68.2857

COIL: 0.8656

CONS_SCORE: 0.4036

DSS_SCORE: 0.628

HELIX: 0.0319

FCONS_SCORE: 1.0426

RIG_SCORE: 0.5751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2659I	TCGA-BF-AAP2	SKCM	TCGA	DSGPGWS	DEG_SCF_TRCP1_1	0.25
p.D2647N	TCGA-D3-A8GM	SKCM	TCGA	DSGPGWS	DEG_SCF_TRCP1_1	0.25
p.P2644S	TCGA-GN-A266	SKCM	TCGA	DSGPGWS	DEG_SCF_TRCP1_1	0.1667
p.G2642A	SIDM00684	Glioblastoma	GDSC	DSGPGWS	DEG_SCF_TRCP1_1	0.1111
p.G2642A	LN-229	central_nervous_system	COSMIC	DSGPGWS	DEG_SCF_TRCP1_1	0.1111
p.D2643N	SIDM00537	Colorectal Carcinoma	GDSC	DSGPGWS	DEG_SCF_TRCP1_1	0.1389
p.D2643N	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGPGWS	DEG_SCF_TRCP1_1	0.1389
p.D2643N	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGPGWS	DEG_SCF_TRCP1_1	0.1389
p.D2643N	GP5d	large_intestine	COSMIC	DSGPGWS	DEG_SCF_TRCP1_1	0.1389
p.G2657D	SIDM00217	Colorectal Carcinoma	GDSC	DSGPGWS	DEG_SCF_TRCP1_1	0.3056
p.G2657D	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGPGWS	DEG_SCF_TRCP1_1	0.3056
p.G2657D	SNU-1040	large_intestine	COSMIC	DSGPGWS	DEG_SCF_TRCP1_1	0.3056
p.P2662L	SIDM00228	Thyroid Gland Carcinoma	GDSC	DSGPGWS	DEG_SCF_TRCP1_1	0.1667
p.D2650N	ACH-002396	Bone Cancer	CCLE	DSGPGWS	DEG_SCF_TRCP1_1	0.6932
p.D2650N	Sarc9371	bone	COSMIC	DSGPGWS	DEG_SCF_TRCP1_1	0.6932
p.P2643Q	SNU-81	large_intestine	COSMIC	DSGPGWS	DEG_SCF_TRCP1_1	0.1389
p.I2640V	KGN	ovary	COSMIC	DSGPGWS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUY3	Protein prune homolog 2	DEG_SCF_TRCP1_1	2650:2656	DSGPGWS	BTRC	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons