DegronMD

Uniprot ID: Q9Y4C8

Source protein: Probable RNA-binding protein 19

Source gene: RBM19

Class: DEG_SCF_TRCP1_1

Location: 175:180

E3 ligase: BTRC

DEGRON score: 0.9978

ASA_SCORE: 84.7

COIL: 0.8033

CONS_SCORE: 0.2329

DSS_SCORE: 0.7523

HELIX: 0.1598

FCONS_SCORE: 1.0349

RIG_SCORE: 0.5677

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G177R	TCGA-CG-4466	STAD	TCGA	DSGQES	DEG_SCF_TRCP1_1	0.7568
p.G177R	DO38695	STAD	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.7568
p.D175N	TCGA-AA-A00N	COAD	TCGA	DSGQES	DEG_SCF_TRCP1_1	0.6932
p.D175N	DO9876	COAD	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.6932
p.D175N	DO234459	ESAD	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.6932
p.E181D	TCGA-D3-A2JP	SKCM	TCGA	DSGQES	DEG_SCF_TRCP1_1	0.3056
p.E181D	DO47407	SKCM	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.3056
p.E181K	TCGA-VQ-A91D	STAD	TCGA	DSGQES	DEG_SCF_TRCP1_1	0.3056
p.E181K	DO51783	STAD	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.3056
p.D173N	TCGA-BS-A0UF	UCEC	TCGA	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.D173N	DO41488	UCEC	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.D173N	SIDM00652	Small Cell Lung Carcinoma	GDSC	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.D173N	ACH-000780	Lung Cancer	CCLE	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.D173N	NCI-H1105	lung	COSMIC	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E182D	SIDM00695	Melanoma	GDSC	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E182D	ACH-000322	Skin Cancer	CCLE	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E182D	ACH-002458	Skin Cancer	CCLE	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E182D	ACH-002459	Skin Cancer	CCLE	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E182D	ACH-002460	Skin Cancer	CCLE	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E182D	HT-144	skin	COSMIC	DSGQES	DEG_SCF_TRCP1_1	0.2778
p.E183K	DO229487	PRAD	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.25
p.G184R	DO228965	LICA	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.2222
p.D168Y	TCGA-05-4424	LUAD	TCGA	DSGQES	DEG_SCF_TRCP1_1	0.1389
p.D168Y	DO23672	LUAD	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.1389
p.A166T	DO229389	BTCA	ICGC	DSGQES	DEG_SCF_TRCP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4C8	Probable RNA-binding protein 19	DEG_SCF_TRCP1_1	175:180	DSGQES	BTRC	0.9978	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons