DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSGQES
Uniprot ID:
Q9Y4C8
Source protein:
Probable RNA-binding protein 19
Source gene:
RBM19
Class:
DEG_SCF_TRCP1_1
Location:
175:180
E3 ligase:
BTRC
DEGRON score:
0.9978
ASA_SCORE:
84.7
COIL:
0.8033
CONS_SCORE:
0.2329
DSS_SCORE:
0.7523
HELIX:
0.1598
FCONS_SCORE:
1.0349
RIG_SCORE:
0.5677
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D168Y
TCGA-05-4424
LUAD
TCGA
DSGQES
DEG_SCF_TRCP1_1
0.1389
p.D168Y
DO23672
LUAD
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.1389
p.D175N
TCGA-AA-A00N
COAD
TCGA
DSGQES
DEG_SCF_TRCP1_1
0.6932
p.D175N
DO9876
COAD
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.6932
p.D175N
DO234459
ESAD
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.6932
p.D173N
TCGA-BS-A0UF
UCEC
TCGA
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.D173N
DO41488
UCEC
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.D173N
SIDM00652
Small Cell Lung Carcinoma
GDSC
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.D173N
ACH-000780
Lung Cancer
CCLE
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.D173N
NCI-H1105
lung
COSMIC
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.G177R
TCGA-CG-4466
STAD
TCGA
DSGQES
DEG_SCF_TRCP1_1
0.7568
p.G177R
DO38695
STAD
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.7568
p.E181D
TCGA-D3-A2JP
SKCM
TCGA
DSGQES
DEG_SCF_TRCP1_1
0.3056
p.E181D
DO47407
SKCM
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.3056
p.E181K
TCGA-VQ-A91D
STAD
TCGA
DSGQES
DEG_SCF_TRCP1_1
0.3056
p.E181K
DO51783
STAD
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.3056
p.A166T
DO229389
BTCA
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.0833
p.G184R
DO228965
LICA
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.2222
p.E183K
DO229487
PRAD
ICGC
DSGQES
DEG_SCF_TRCP1_1
0.25
p.E182D
SIDM00695
Melanoma
GDSC
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.E182D
ACH-000322
Skin Cancer
CCLE
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.E182D
ACH-002458
Skin Cancer
CCLE
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.E182D
ACH-002459
Skin Cancer
CCLE
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.E182D
ACH-002460
Skin Cancer
CCLE
DSGQES
DEG_SCF_TRCP1_1
0.2778
p.E182D
HT-144
skin
COSMIC
DSGQES
DEG_SCF_TRCP1_1
0.2778
Drug responses associated with RBM19 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGQES
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4C8
Probable RNA-binding protein 19
DEG_SCF_TRCP1_1
175:180
DSGQES
BTRC
0.9978
More...