DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SCF_TRCP1_1

Location: 617:623

E3 ligase: BTRC

DEGRON score: 0.9854

ASA_SCORE: 66.4286

COIL: 0.8141

CONS_SCORE: 0.3909

DSS_SCORE: 0.5795

HELIX: 0.0703

FCONS_SCORE: 1.0461

RIG_SCORE: 0.6164

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L621F	DO14998	HNSC	ICGC	DSGQGST	DEG_SCF_TRCP1_1	0.6981
p.P622S	DO47625	SKCM	ICGC	DSGQGST	DEG_SCF_TRCP1_1	0.6752
p.T623A	TCGA-B5-A11U	UCEC	TCGA	DSGQGST	DEG_SCF_TRCP1_1	0.6028
p.P616H	DO46836	RECA	ICGC	DSGQGST	DEG_SCF_TRCP1_1	0.3056
p.R613H	DO8119	COAD	ICGC	DSGQGST	DEG_SCF_TRCP1_1	0.2222
p.S628L	TCGA-CM-6162	COAD	TCGA	DSGQGST	DEG_SCF_TRCP1_1	0.1944
p.S628P	SIDM00333	Endometrial Carcinoma	GDSC	DSGQGST	DEG_SCF_TRCP1_1	0.1944
p.S628P	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGQGST	DEG_SCF_TRCP1_1	0.1944
p.S628P	MFE-319	endometrium	COSMIC	DSGQGST	DEG_SCF_TRCP1_1	0.1944
p.P631R	DO219912	DLBC	ICGC	DSGQGST	DEG_SCF_TRCP1_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SCF_TRCP1_1	617:623	DSGQGST	BTRC	0.9854	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons