DegronMD

Uniprot ID: Q9P202

Source protein: Whirlin

Source gene: WHRN

Class: DEG_SCF_TRCP1_1

Location: 755:761

E3 ligase: BTRC

DEGRON score: 0.9956

ASA_SCORE: 67.8

COIL: 0.7257

CONS_SCORE: 0.6479

DSS_SCORE: 0.6594

HELIX: 0.1384

FCONS_SCORE: 1.3355

RIG_SCORE: 0.6194

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E770K	SIDM00611	Kidney Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.0833
p.E770K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.0833
p.E770K	KMRC-1	kidney	COSMIC	DSGQTLS	DEG_SCF_TRCP1_1	0.0833
p.E770K	NCI-H1573	lung	COSMIC	DSGQTLS	DEG_SCF_TRCP1_1	0.0833
p.Q752H	SIDM01039	Other Solid Cancers	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.25
p.Q752H	SIDM00539	Esophageal Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.25
p.Q752H	SIDM01409	Bladder Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.25
p.Q752H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.25
p.Q752H	SIDM01752	Pancreatic Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.25
p.S754L	SIDM01551	Gastric Carcinoma	GDSC	DSGQTLS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P202	Whirlin	DEG_SCF_TRCP1_1	755:761	DSGQTLS	BTRC	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons