DegronMD

Uniprot ID: Q00613

Source protein: Heat shock factor protein 1

Source gene: HSF1

Class: DEG_SCF_TRCP1_1

Location: 215:221

E3 ligase: BTRC

DEGRON score: 0.9949

ASA_SCORE: 83.8857

COIL: 0.8776

CONS_SCORE: 0.3417

DSS_SCORE: 0.3502

HELIX: 0.0907

FCONS_SCORE: 1.0128

RIG_SCORE: 0.6478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R207G	TCGA-A6-2681	COAD	TCGA	DSGSAHS	DEG_SCF_TRCP1_1	0.1111
p.S221Y	TCGA-B5-A11E	UCEC	TCGA	DSGSAHS	DEG_SCF_TRCP1_1	0.712
p.K208N	TCGA-GN-A26C	SKCM	TCGA	DSGSAHS	DEG_SCF_TRCP1_1	0.5833
p.R231C	DO227976	COCA	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.0556
p.R231C	DO22237	LGG	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.0556
p.R222K	DO225404	LAML	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.3056
p.P211L	DO37430	SKCM	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.2222
p.P223L	DO47430	SKCM	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.2778
p.E221K	DO41271	UCEC	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.7022
p.M212V	DO43779	UCEC	ICGC	DSGSAHS	DEG_SCF_TRCP1_1	0.25
p.R227Q	SIDM00150	Colorectal Carcinoma	GDSC	DSGSAHS	DEG_SCF_TRCP1_1	0.1667
p.R227Q	KM12	large_intestine	COSMIC	DSGSAHS	DEG_SCF_TRCP1_1	0.1667
p.P208L	ACH-000899	Skin Cancer	CCLE	DSGSAHS	DEG_SCF_TRCP1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00613	Heat shock factor protein 1	DEG_SCF_TRCP1_1	215:221	DSGSAHS	BTRC	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons